ENSG00000169676


Homo sapiens

Features
Gene ID: ENSG00000169676
  
Biological name :DRD5
  
Synonyms : dopamine receptor D5 / DRD5 / P21918
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.1
Gene start: 9781680
Gene end: 9784009
  
Corresponding Affymetrix probe sets: 208486_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306129
NCBI entrez gene - 1816     See in Manteia.
OMIM - 126453
RefSeq - NM_000798
RefSeq Peptide - NP_000789
swissprot - P21918
Ensembl - ENSG00000169676
  
Related genetic diseases (OMIM): 143465 - {Attention deficit-hyperactivity disorder, susceptibility to}, 143465
  606798 - {Blepharospasm, primary benign}, 606798
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX530018.1ENSDARG00000037576Danio rerio
 DRD5ENSGALG00000014975Gallus gallus
 Drd5ENSMUSG00000039358Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DRD1 / P21728 / dopamine receptor D1ENSG0000018484553
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359129
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874826
DRD2 / P14416 / dopamine receptor D2ENSG0000014929526
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925226
HRH2 / P25021 / histamine receptor H2ENSG0000011374926
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877825
DRD3 / P35462 / dopamine receptor D3ENSG0000015157724
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591423
DRD4 / P21917 / dopamine receptor D4ENSG0000006969623
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724622
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000497  Dopamine D5 receptor
 IPR000929  Dopamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001963 synaptic transmission, dopaminergic NAS
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0001992 regulation of systemic arterial blood pressure by vasopressin IEA
 biological_processGO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA
 biological_processGO:0006874 cellular calcium ion homeostasis TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IDA
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission NAS
 biological_processGO:0007612 learning IBA
 biological_processGO:0007617 mating behavior IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0019226 transmission of nerve impulse IEA
 biological_processGO:0033861 negative regulation of NAD(P)H oxidase activity IDA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0045762 positive regulation of adenylate cyclase activity NAS
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045924 regulation of female receptivity IEA
 biological_processGO:0046960 sensitization IEA
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway TAS
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0071870 cellular response to catecholamine stimulus IDA
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0060170 ciliary membrane IDA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity IDA
 molecular_functionGO:0035240 dopamine binding IDA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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