ENSMUSG00000013089


Mus musculus

Features
Gene ID: ENSMUSG00000013089
  
Biological name :Etv5
  
Synonyms : ETS translocation variant 5 / Etv5 / Q9CXC9
  
Possible biological names infered from orthology : ETS variant 5 / P41161
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 22381309
Gene end: 22439719
  
Corresponding Affymetrix probe sets: 10363901 (MoGene1.0st)   10438626 (MoGene1.0st)   1420998_at (Mouse Genome 430 2.0 Array)   1428142_at (Mouse Genome 430 2.0 Array)   1450082_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132210
Ensembl peptide - ENSMUSP00000078551
Ensembl peptide - ENSMUSP00000128338
Ensembl peptide - ENSMUSP00000131791
NCBI entrez gene - 104156     See in Manteia.
MGI - MGI:1096867
RefSeq - NM_023794
RefSeq - XM_006521657
RefSeq Peptide - NP_076283
RefSeq Peptide - NP_001345357
swissprot - F6Q487
swissprot - Q8BJR1
swissprot - Q9CXC9
swissprot - E9Q288
Ensembl - ENSMUSG00000013089
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ETV5ENSGALG00000005768Gallus gallus
 ETV5ENSG00000244405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415158
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772449
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073218
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203518
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289518
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608717
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897615
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631113
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519713
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643612
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338212
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940612
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839811
Gm4881 / AC010616.1*ENSMUSG0000010836711
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR006715  PEA3-type ETS-domain transcription factor, N-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048133 male germ-line stem cell asymmetric division IEA
 biological_processGO:0050807 regulation of synapse organization IMP
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IDA
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000413 polyphalangy "increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5tm1Kmm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0000524 reduced renal tubule number "fewer loops of Henle and collecting ducts" [J:40203]
Show

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Etv5tm1.2Xsun/Etv5tm1.2Xsun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0002243 abnormal vomeronasal organ morphology "any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells and lies anteriorly in the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5tm1Kmm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
Show

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5tm1Kmm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
Show

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Pcyt2tm1.1Suja/Pcyt2tm1.1Suja,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Etv5sco/Etv5sco
Genetic Background: involves: C57BL/6JAnu * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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