ENSMUSG00000026436


Mus musculus

Features
Gene ID: ENSMUSG00000026436
  
Biological name :Elk4
  
Synonyms : Elk4 / ETS domain-containing protein Elk-4 / P41158
  
Possible biological names infered from orthology : ELK4, ETS transcription factor / P28324
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 132007607
Gene end: 132032612
  
Corresponding Affymetrix probe sets: 10349752 (MoGene1.0st)   1422233_at (Mouse Genome 430 2.0 Array)   1427162_a_at (Mouse Genome 430 2.0 Array)   1447571_at (Mouse Genome 430 2.0 Array)   1450549_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027696
Ensembl peptide - ENSMUSP00000083743
Ensembl peptide - ENSMUSP00000114255
Ensembl peptide - ENSMUSP00000118880
NCBI entrez gene - 13714     See in Manteia.
MGI - MGI:102853
RefSeq - XM_017315041
RefSeq - XM_006529128
RefSeq - XM_006529129
RefSeq - XM_006529130
RefSeq - XM_006529131
RefSeq - NM_007923
RefSeq - XM_006529126
RefSeq - XM_006529127
RefSeq Peptide - NP_031949
swissprot - F6ZCI1
swissprot - A0A1B0GXH8
swissprot - P41158
Ensembl - ENSMUSG00000026436
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01069595.1ENSDARG00000024431Danio rerio
 elk4ENSDARG00000077092Danio rerio
 ENSGALG00000042137Gallus gallus
 ELK4ENSG00000158711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839847
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940638
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085722
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338221
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772416
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073215
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519715
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608715
Gm4881 / AC010616.1*ENSMUSG0000010836715
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308914
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415114
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897613
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289512
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203512
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0070932 histone H3 deacetylation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0004917 abnormal T cell selection "any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation" [GO:0045058]
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Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Elk4tm1Rtr/Elk4tm1Rtr,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Elk4tm1Rtr/Elk4tm1Rtr,Tg(TcrLCMV)327Sdz/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Elk4tm1Rtr/Elk4tm1Rtr,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Elk4tm1Rtr/Elk4tm1Rtr,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Elk4tm1Rtr/Elk4tm1Rtr,Tg(TcrLCMV)327Sdz/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Elk4tm1Rtr/Elk4tm1Rtr,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2J

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Giprtm1Thor/Giprtm1Thor,Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Elk4tm1a(EUCOMM)Wtsi/H

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Elk4tm1Rtr/Elk4tm1Rtr,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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