ENSMUSG00000040732


Mus musculus

Features
Gene ID: ENSMUSG00000040732
  
Biological name :Erg
  
Synonyms : Erg / P81270 / Transcriptional regulator ERG
  
Possible biological names infered from orthology : ERG, ETS transcription factor / P11308
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 95359169
Gene end: 95586593
  
Corresponding Affymetrix probe sets: 10441093 (MoGene1.0st)   1425370_a_at (Mouse Genome 430 2.0 Array)   1440244_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132766
Ensembl peptide - ENSMUSP00000114072
Ensembl peptide - ENSMUSP00000134930
Ensembl peptide - ENSMUSP00000135568
Ensembl peptide - ENSMUSP00000076949
Ensembl peptide - ENSMUSP00000109477
Ensembl peptide - ENSMUSP00000109479
Ensembl peptide - ENSMUSP00000112698
Ensembl peptide - ENSMUSP00000113723
NCBI entrez gene - 13876     See in Manteia.
MGI - MGI:95415
RefSeq - XM_006522904
RefSeq - NM_001302152
RefSeq - NM_001302153
RefSeq - NM_001302154
RefSeq - NM_001302179
RefSeq - NM_001302183
RefSeq - NM_133659
RefSeq - XM_006522894
RefSeq - XM_006522895
RefSeq - XM_006522896
RefSeq - XM_006522899
RefSeq - XM_006522900
RefSeq - XM_006522903
RefSeq Peptide - NP_001289081
RefSeq Peptide - NP_001289083
RefSeq Peptide - NP_001289108
RefSeq Peptide - NP_001289112
RefSeq Peptide - NP_598420
RefSeq Peptide - NP_001289082
swissprot - D3YU51
swissprot - P81270
swissprot - Q3UQJ4
swissprot - B7ZND4
swissprot - E9PY05
swissprot - H3BJC4
swissprot - H3BKX4
swissprot - I1E4Y2
Ensembl - ENSMUSG00000040732
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ERGENSGALG00000016058Gallus gallus
 ERGENSG00000157554Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608762
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289527
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519724
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203524
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897623
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415119
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308919
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772419
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085716
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631116
Gm4881 / AC010616.1*ENSMUSG0000010836715
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338215
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940614
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839814
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643613


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:2000504 positive regulation of blood vessel remodeling IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Bhlhe40tm1Tan/Bhlhe40+,Bhlhe41tm1Mjro/Bhlhe41tm1Mjro
Genetic Background: B6.129-Bhlhe40tm1Tan Bhlhe41tm1Mjro

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2

Allelic Composition: Ergmld2/Erg+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fli1tm1Dkw/Fli1+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0004125 abnormal venule morphology "any structural anomaly in the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fli1tm1Dkw/Fli1+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ergmld2/Erg+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0006137 venoocclusion "blockage of blood flow through one or more veins" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ergmld2/Erg+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ergtm1.1Sho/Ergtm1.1Sho,Ptentm1Hwu/Ptentm1Hwu,Tmprss2tm3Sho/Tmprss2tm3Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syktm2.1(ZAP70)Fkfr/Syktm2.1(ZAP70)Fkfr
Genetic Background: B6.129-Syktm2.1(ZAP70)Fkfr

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fli1tm1Dkw/Fli1+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

 MP:0020161 increased vascular endothelial cell proliferation "increase in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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