ENSG00000157554


Homo sapiens

Features
Gene ID: ENSG00000157554
  
Biological name :ERG
  
Synonyms : ERG / ERG, ETS transcription factor / P11308
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.2
Gene start: 38380027
Gene end: 38661780
  
Corresponding Affymetrix probe sets: 1563392_at (Human Genome U133 Plus 2.0 Array)   211626_x_at (Human Genome U133 Plus 2.0 Array)   213541_s_at (Human Genome U133 Plus 2.0 Array)   222079_at (Human Genome U133 Plus 2.0 Array)   241926_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000381882
Ensembl peptide - ENSP00000381881
Ensembl peptide - ENSP00000381891
Ensembl peptide - ENSP00000415659
Ensembl peptide - ENSP00000414150
Ensembl peptide - ENSP00000396268
Ensembl peptide - ENSP00000394694
Ensembl peptide - ENSP00000288319
Ensembl peptide - ENSP00000381871
Ensembl peptide - ENSP00000381877
Ensembl peptide - ENSP00000381879
NCBI entrez gene - 2078     See in Manteia.
OMIM - 165080
RefSeq - NM_182918
RefSeq - NM_001136154
RefSeq - NM_001136155
RefSeq - NM_001243428
RefSeq - NM_001243429
RefSeq - NM_001243432
RefSeq - NM_001291391
RefSeq - NM_001331025
RefSeq - NM_004449
RefSeq - XM_011529486
RefSeq - XM_011529487
RefSeq - XM_017028287
RefSeq - XM_017028288
RefSeq - XM_017028289
RefSeq Peptide - NP_001129626
RefSeq Peptide - NP_001129627
RefSeq Peptide - NP_001230358
RefSeq Peptide - NP_001230361
RefSeq Peptide - NP_001278320
RefSeq Peptide - NP_001317954
RefSeq Peptide - NP_004440
RefSeq Peptide - NP_891548
RefSeq Peptide - NP_001230357
swissprot - B5MDW0
swissprot - A8MZ24
swissprot - A8MX39
swissprot - A0A0C4DG41
swissprot - A0A088AWP2
swissprot - P11308
Ensembl - ENSG00000157554
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ERGENSGALG00000016058Gallus gallus
 ErgENSMUSG00000040732Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FLI1 / Q01543 / Fli-1 proto-oncogene, ETS transcription factorENSG0000015170263
ETS2 / P15036 / ETS proto-oncogene 2, transcription factorENSG0000015755727
ETS1 / P14921 / ETS proto-oncogene 1, transcription factorENSG0000013495425
FEV / Q99581 / FEV, ETS transcription factorENSG0000016349724
GABPA / Q06546 / GA binding protein transcription factor alpha subunitENSG0000015472723
ETV4 / P43268 / ETS variant 4ENSG0000017583219
ETV5 / P41161 / ETS variant 5ENSG0000024440519
ETV1 / P50549 / ETS variant 1ENSG0000000646819
ETV2 / O00321 / ETS variant 2ENSG0000010567218
ERF / P50548 / ETS2 repressor factorENSG0000010572216
ETV3 / P41162 / ETS variant 3ENSG0000011703615
AC010616.1ENSG0000026804115
ELK3 / P41970 / ELK3, ETS transcription factorENSG0000011114514
ELK1 / P19419 / ELK1, ETS transcription factorENSG0000012676714
ETV3L / Q6ZN32 / ETS variant 3 likeENSG0000025383114
ELK4 / P28324 / ELK4, ETS transcription factorENSG0000015871113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:2000504 positive regulation of blood vessel remodeling IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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