ENSG00000111145


Homo sapiens

Features
Gene ID: ENSG00000111145
  
Biological name :ELK3
  
Synonyms : ELK3 / ELK3, ETS transcription factor / P41970
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q23.1
Gene start: 96194382
Gene end: 96269835
  
Corresponding Affymetrix probe sets: 206127_at (Human Genome U133 Plus 2.0 Array)   221773_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000228741
Ensembl peptide - ENSP00000447857
Ensembl peptide - ENSP00000449420
Ensembl peptide - ENSP00000449430
Ensembl peptide - ENSP00000446806
NCBI entrez gene - 2004     See in Manteia.
OMIM - 600247
RefSeq - XM_006719275
RefSeq - NM_005230
RefSeq Peptide - NP_005221
swissprot - G3V1Z7
swissprot - H0YIH6
swissprot - F8VZQ0
swissprot - P41970
swissprot - F8VUJ0
swissprot - A0A024RBE2
Ensembl - ENSG00000111145
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elk3ENSDARG00000018688Danio rerio
 ELK3ENSGALG00000043701Gallus gallus
 Elk3ENSMUSG00000008398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ELK4 / P28324 / ELK4, ETS transcription factorENSG0000015871152
ELK1 / P19419 / ELK1, ETS transcription factorENSG0000012676739
ERF / P50548 / ETS2 repressor factorENSG0000010572221
ETV3 / P41162 / ETS variant 3ENSG0000011703620
ETV3L / Q6ZN32 / ETS variant 3 likeENSG0000025383116
ERG / P11308 / ERG, ETS transcription factorENSG0000015755416
FEV / Q99581 / FEV, ETS transcription factorENSG0000016349716
FLI1 / Q01543 / Fli-1 proto-oncogene, ETS transcription factorENSG0000015170216
ETV4 / P43268 / ETS variant 4ENSG0000017583216
AC010616.1ENSG0000026804115
ETV1 / P50549 / ETS variant 1ENSG0000000646814
GABPA / Q06546 / GA binding protein transcription factor alpha subunitENSG0000015472714
ETS1 / P14921 / ETS proto-oncogene 1, transcription factorENSG0000013495414
ETV5 / P41161 / ETS variant 5ENSG0000024440514
ETS2 / P15036 / ETS proto-oncogene 2, transcription factorENSG0000015755713
ETV2 / O00321 / ETS variant 2ENSG0000010567211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032422 purine-rich negative regulatory element binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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