ENSG00000126767


Homo sapiens

Features
Gene ID: ENSG00000126767
  
Biological name :ELK1
  
Synonyms : ELK1 / ELK1, ETS transcription factor / P19419
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p11.23
Gene start: 47635521
Gene end: 47650604
  
Corresponding Affymetrix probe sets: 203617_x_at (Human Genome U133 Plus 2.0 Array)   210376_x_at (Human Genome U133 Plus 2.0 Array)   210850_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366182
Ensembl peptide - ENSP00000247161
Ensembl peptide - ENSP00000345585
NCBI entrez gene - 2002     See in Manteia.
OMIM - 311040
RefSeq - XM_017029339
RefSeq - NM_001114123
RefSeq - NM_001257168
RefSeq - NM_005229
RefSeq Peptide - NP_001107595
RefSeq Peptide - NP_001244097
RefSeq Peptide - NP_005220
swissprot - P19419
swissprot - A0A024R1A7
Ensembl - ENSG00000126767
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elk1ENSDARG00000078066Danio rerio
 Elk1ENSMUSG00000009406Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ELK3 / P41970 / ELK3, ETS transcription factorENSG0000011114537
ELK4 / P28324 / ELK4, ETS transcription factorENSG0000015871137
ETV3 / P41162 / ETS variant 3ENSG0000011703622
ERF / P50548 / ETS2 repressor factorENSG0000010572222
ETV3L / Q6ZN32 / ETS variant 3 likeENSG0000025383117
FEV / Q99581 / FEV, ETS transcription factorENSG0000016349716
ERG / P11308 / ERG, ETS transcription factorENSG0000015755416
FLI1 / Q01543 / Fli-1 proto-oncogene, ETS transcription factorENSG0000015170215
AC010616.1ENSG0000026804115
ETV5 / P41161 / ETS variant 5ENSG0000024440514
ETV4 / P43268 / ETS variant 4ENSG0000017583214
ETV1 / P50549 / ETS variant 1ENSG0000000646814
ETS1 / P14921 / ETS proto-oncogene 1, transcription factorENSG0000013495414
ETS2 / P15036 / ETS proto-oncogene 2, transcription factorENSG0000015755713
GABPA / Q06546 / GA binding protein transcription factor alpha subunitENSG0000015472713
ETV2 / O00321 / ETS variant 2ENSG0000010567211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0071396 cellular response to lipid IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071774 response to fibroblast growth factor ISS
 biological_processGO:1901216 positive regulation of neuron death IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
ERK/MAPK targets


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction






 

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