ENSG00000134954


Homo sapiens

Features
Gene ID: ENSG00000134954
  
Biological name :ETS1
  
Synonyms : ETS1 / ETS proto-oncogene 1, transcription factor / P14921
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q24.3
Gene start: 128458761
Gene end: 128587558
  
Corresponding Affymetrix probe sets: 1555355_a_at (Human Genome U133 Plus 2.0 Array)   214447_at (Human Genome U133 Plus 2.0 Array)   224833_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476649
Ensembl peptide - ENSP00000324578
Ensembl peptide - ENSP00000376436
Ensembl peptide - ENSP00000435666
Ensembl peptide - ENSP00000441430
Ensembl peptide - ENSP00000433500
NCBI entrez gene - 2113     See in Manteia.
OMIM - 164720
RefSeq - XM_017017317
RefSeq - NM_001143820
RefSeq - NM_001162422
RefSeq - NM_005238
RefSeq - XM_011542650
RefSeq - XM_011542651
RefSeq - XM_011542652
RefSeq - XM_017017314
RefSeq - XM_017017315
RefSeq - XM_017017316
RefSeq - XM_011542649
RefSeq Peptide - NP_001155894
RefSeq Peptide - NP_001317380
RefSeq Peptide - NP_005229
RefSeq Peptide - NP_001137292
swissprot - P14921
swissprot - V9GYD6
Ensembl - ENSG00000134954
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ets2ENSDARG00000103980Danio rerio
 ETS1ENSGALG00000001143Gallus gallus
 Ets1ENSMUSG00000032035Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ETS2 / P15036 / ETS proto-oncogene 2, transcription factorENSG0000015755750
ERG / P11308 / ERG, ETS transcription factorENSG0000015755425
FLI1 / Q01543 / Fli-1 proto-oncogene, ETS transcription factorENSG0000015170224
GABPA / Q06546 / GA binding protein transcription factor alpha subunitENSG0000015472724
ETV1 / P50549 / ETS variant 1ENSG0000000646821
ETV4 / P43268 / ETS variant 4ENSG0000017583221
ETV5 / P41161 / ETS variant 5ENSG0000024440519
ETV2 / O00321 / ETS variant 2ENSG0000010567218
FEV / Q99581 / FEV, ETS transcription factorENSG0000016349716
ETV3 / P41162 / ETS variant 3ENSG0000011703613
AC010616.1ENSG0000026804113
ETV3L / Q6ZN32 / ETS variant 3 likeENSG0000025383113
ERF / P50548 / ETS2 repressor factorENSG0000010572213
ELK1 / P19419 / ELK1, ETS transcription factorENSG0000012676712
ELK3 / P41970 / ELK3, ETS transcription factorENSG0000011114511
ELK4 / P28324 / ELK4, ETS transcription factorENSG0000015871111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016311  Transforming protein C-ets
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010715 regulation of extracellular matrix disassembly IEA
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030578 PML body organization IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IDA
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048870 cell motility IMP
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0051272 positive regulation of cellular component movement IMP
 biological_processGO:0060055 angiogenesis involved in wound healing IEA
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding IEA


Pathways (from Reactome)
Pathway description
Oncogene Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction






 

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