ENSDARG00000053868


Danio rerio

Features
Gene ID: ENSDARG00000053868
  
Biological name :etv2
  
Synonyms : ets variant 2 / etv2
  
Possible biological names infered from orthology : ETS translocation variant 2 / O00321 / P41163
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 42007090
Gene end: 42014272
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000045402
Ensembl peptide - ENSDARP00000148051
NCBI entrez gene - 555766     See in Manteia.
RefSeq - NM_001037375
RefSeq Peptide - NP_001032452
swissprot - Q30JB6
ZFIN ID - ZDB-GENE-050622-14
Ensembl - ENSDARG00000053868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ETV2ENSG00000105672Homo sapiens
 Etv2ENSMUSG00000006311Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ets2 / v-ets avian erythroblastosis virus E26 oncogene homolog 2 / ETS1* / P14921* / P27577* / Protein C-ets-1 * / ETS proto-oncogene 1, transcription factor*ENSDARG0000010398029
fli1b / Fli-1 proto-oncogene, ETS transcription factor bENSDARG0000004008022
fli1a / Fli-1 proto-oncogene, ETS transcription factor a / FLI1* / P26323* / Q01543* / Fli-1 proto-oncogene, ETS transcription factor* / Friend leukemia integration 1 transcription factor *ENSDARG0000005463222
etv1 / ets variant 1ENSDARG0000010195920
gabpa / GA binding protein transcription factor, alpha subunit / Q00422* / Q06546* / GA-binding protein alpha chain *ENSDARG0000006928920
erg / v-ets avian erythroblastosis virus E26 oncogene homolog / FLI1* / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSDARG0000007730420
etv5b / ets variant 5bENSDARG0000004451119
etv5a / ets variant 5a / ETV1* / P41164* / P50549* / ETS variant 1* / ETS translocation variant 1 *ENSDARG0000006976319
etv4 / ets variant 4 / P28322* / P43268* / ETS translocation variant 4 *ENSDARG0000001830318
fev / A3FEM2 / FEV (ETS oncogene family)ENSDARG0000000924218
elk4 / ELK4, ETS-domain protein / P28324* / P41158* / ELK4, ETS transcription factor* / ETS domain-containing protein Elk-4 *ENSDARG0000007709214
erfl3 / Ets2 repressor factor like 3ENSDARG0000006280114
erf / Ets2 repressor factorENSDARG0000006341714
elk1 / ELK1, member of ETS oncogene family / P19419* / P41969* / ELK1, ETS transcription factor* / ETS domain-containing protein Elk-1 *ENSDARG0000007806614
erfl1 / Ets2 repressor factor like 1 / ERF* / Gm4881* / P50548* / AC010616.1* / ETS2 repressor factor*ENSDARG0000008689214
elk3 / ELK3, ETS-domain protein / P41970* / P41971* / ELK3, ETS transcription factor* / ETS domain-containing protein Elk-3 *ENSDARG0000001868814
si:ch211-265g22.4ENSDARG0000007651213
CABZ01069595.1 / ELK4* / P28324* / ELK4, ETS transcription factor*ENSDARG000000244318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR011991  ArsR-like helix-turn-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001944 vasculature development IGI
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0030223 neutrophil differentiation IMP
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035779 angioblast cell differentiation IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0060217 hemangioblast cell differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta absent , abnormal
dorsal aorta decreased size , abnormal
Show

 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm amount , ameliorated
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein absent , abnormal
Show

 ZFA:0001073 axial vasculature axial vasculature apoptotic process increased process quality , abnormal
axial vasculature malformed , abnormal
axial vasculature vasculogenesis process quality , abnormal
Show

 ZFA:0001079 blood vasculature blood vasculature disorganized , abnormal
blood vasculature lacks parts or has fewer parts of type blood vessel , abnormal
blood vasculature morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism neoplasm decreased size , abnormal
whole organism neoplasm decreased amount , abnormal
whole organism neoplasm lacks all parts of type angiogenic sprout , abnormal
whole organism neoplasm lacks parts or has fewer parts of type blood vessel , abnormal
whole organism neoplasm has fewer parts of type blood vessel , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel hypoplastic , abnormal
intersegmental vessel morphology , abnormal
intersegmental vessel absent , abnormal
intersegmental vessel spatial pattern , abnormal
intersegmental vessel sprouting angiogenesis disrupted , abnormal
intersegmental vessel aplastic , abnormal
intersegmental vessel decreased amount , abnormal
intersegmental vessel sprouting angiogenesis delayed , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel sprouting angiogenesis decreased process quality , abnormal
intersegmental vessel sprouting angiogenesis arrested , abnormal
Show

 ZFA:0001286 caudal vein plexus caudal vein plexus decreased amount , abnormal
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 ZFA:0001319 myocardium myocardium fused with myocardium , ameliorated
Show

 ZFA:0001338 intestine intestine decreased size , abnormal
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 ZFA:0001346 interrenal primordium interrenal primordium bilateral , abnormal
interrenal primordium left side unfused from interrenal primordium right side, abnormal
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 ZFA:0001639 vascular endothelium vascular endothelium mislocalised , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel hypoplastic , abnormal
dorsal longitudinal anastomotic vessel malformed , abnormal
Show

 ZFA:0005040 posterior lateral mesoderm posterior lateral mesoderm morphology , abnormal
Show

 ZFA:0005042 posterior lateral plate mesoderm posterior lateral plate mesoderm amount , ameliorated
Show

 ZFA:0005249 vasculature vasculature increased amount , abnormal
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 ZFA:0005490 myocardial precursor myocardial precursor cardioblast migration to the midline involved in heart field formation occurrence , ameliorated
Show

 ZFA:0009044 blood cell blood cell decreased amount , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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