ENSDARG00000055493


Danio rerio

Features
Gene ID: ENSDARG00000055493
  
Biological name :hic1
  
Synonyms : hic1 / hypermethylated in cancer 1
  
Possible biological names infered from orthology : HIC ZBTB transcriptional repressor 1 / Q14526
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 25681044
Gene end: 25690267
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000116361
Ensembl peptide - ENSDARP00000072319
NCBI entrez gene - 436585     See in Manteia.
RefSeq - NM_001002314
RefSeq Peptide - NP_001002314
swissprot - E9QBS8
swissprot - Q70ZY9
ZFIN ID - ZDB-GENE-040713-2
Ensembl - ENSDARG00000055493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HIC1ENSGALG00000042077Gallus gallus
 HIC1ENSG00000177374Homo sapiens
 Hic1ENSMUSG00000043099Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hic2 / Q90W33 / hypermethylated in cancer 2 / Q96JB3* / HIC ZBTB transcriptional repressor 2*ENSDARG0000010049734
hic1l / hypermethylated in cancer 1 like / HIC2* / Q96JB3* / Q9JLZ6* / HIC ZBTB transcriptional repressor 2* / Hypermethylated in cancer 2 protein *ENSDARG0000004566028
Q1L8W0 / zbtb18 / zinc finger and BTB domain containing 18 / Q99592* / Q9WUK6*ENSDARG0000002822817
zbtb42 / zinc finger and BTB domain containing 42ENSDARG0000010276114
zbtb7c / zinc finger and BTB domain containing 7C / A1YPR0*ENSDARG0000010098514
zbtb8b / zinc finger and BTB domain containing 8B / Q8NAP8* / AL033529.1*ENSDARG0000003588913
zbtb3 / zinc finger and BTB domain containing 3 / Q91X45* / Q9H5J0*ENSDARG0000003623513
zbtb7a / zinc finger and BTB domain containing 7a / O88939* / O95365*ENSDARG0000003989913
zbtb46 / zinc finger and BTB domain containing 46 / Q86UZ6* / Q8BID6*ENSDARG0000007819112
zbtb7b / zinc finger and BTB domain containing 7B / O15156* / Q64321*ENSDARG0000002189112
zbtb10 / zinc finger and BTB domain containing 10 / Q96DT7*ENSDARG0000007710112
zbtb8a / zinc finger and BTB domain containing 8A / Q96BR9* / Q9CWH1*ENSDARG0000005922611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR028424  Hypermethylated in cancer 1 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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