ENSMUSG00000043099


Mus musculus

Features
Gene ID: ENSMUSG00000043099
  
Biological name :Hic1
  
Synonyms : Hic1 / HIC ZBTB transcriptional repressor 1
  
Possible biological names infered from orthology : Q14526
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 75164565
Gene end: 75169519
  
Corresponding Affymetrix probe sets: 10388389 (MoGene1.0st)   1449226_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053483
NCBI entrez gene - 15248     See in Manteia.
MGI - MGI:1338010
RefSeq - NM_010430
RefSeq - XM_017314294
RefSeq Peptide - NP_034560
swissprot - Z4YJP0
Ensembl - ENSMUSG00000043099
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hic1ENSDARG00000055493Danio rerio
 HIC1ENSGALG00000042077Gallus gallus
 HIC1ENSG00000177374Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hic2 / Q9JLZ6 / Hypermethylated in cancer 2 protein / Q96JB3* / HIC ZBTB transcriptional repressor 2*ENSMUSG0000005024032
Q64321 / Zbtb7b / zinc finger and BTB domain containing 7B / O15156*ENSMUSG0000002804214
Q8VCZ7 / Zbtb7c / zinc finger and BTB domain containing 7C / A1YPR0*ENSMUSG0000004464613
Q9WUK6 / Zbtb18 / zinc finger and BTB domain containing 18 / Q99592*ENSMUSG0000006365913
Zbtb3 / Q91X45 / zinc finger and BTB domain containing 3 / Q9H5J0*ENSMUSG0000007166113
Zbtb5 / Q7TQG0 / zinc finger and BTB domain containing 5 / O15062*ENSMUSG0000004965713
O88939 / Zbtb7a / zinc finger and BTB domain containing 7a / O95365*ENSMUSG0000003501113
Q811H0 / Zbtb42 / zinc finger and BTB domain containing 42 / B2RXF5*ENSMUSG0000003763812
Q8BID6 / Zbtb46 / zinc finger and BTB domain containing 46 / Q86UZ6*ENSMUSG0000002758312
Zbtb10 / zinc finger and BTB domain containing 10 / Q96DT7*ENSMUSG0000006911411
Zbtb8b / zinc finger and BTB domain containing 8b / Q8NAP8* / AL033529.1*ENSMUSG0000004848511
Q9CWH1 / Zbtb8a / zinc finger and BTB domain containing 8a / Q96BR9*ENSMUSG0000002880710


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR028424  Hypermethylated in cancer 1 protein
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001272 increased metastatic potential 
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0003104 acrania "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003384 abnormal ventral body wall "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009025 abnormal brain dura mater morphology "any structural anomaly of the fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010348 increased pancreatic islet cell carcinoma incidence "greater than the expected number of malignant neoplasms arising in the pancreatic islet cells, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

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