ENSMUSG00000050240


Mus musculus

Features
Gene ID: ENSMUSG00000050240
  
Biological name :Hic2
  
Synonyms : Hic2 / Hypermethylated in cancer 2 protein / Q9JLZ6
  
Possible biological names infered from orthology : HIC ZBTB transcriptional repressor 2 / Q96JB3
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 17233587
Gene end: 17263429
  
Corresponding Affymetrix probe sets: 10433973 (MoGene1.0st)   1427581_at (Mouse Genome 430 2.0 Array)   1437571_at (Mouse Genome 430 2.0 Array)   1454944_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087656
NCBI entrez gene - 58180     See in Manteia.
MGI - MGI:1929869
RefSeq - NM_178922
RefSeq Peptide - NP_849253
swissprot - Q9JLZ6
Ensembl - ENSMUSG00000050240
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hic1lENSDARG00000045660Danio rerio
 hic2ENSDARG00000100497Danio rerio
 HIC2ENSGALG00000033416Gallus gallus
 HIC2ENSG00000169635Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hic1 / HIC ZBTB transcriptional repressor 1 / Q14526*ENSMUSG0000004309946
Q9WUK6 / Zbtb18 / zinc finger and BTB domain containing 18 / Q99592*ENSMUSG0000006365920
Q64321 / Zbtb7b / zinc finger and BTB domain containing 7B / O15156*ENSMUSG0000002804219
O88939 / Zbtb7a / zinc finger and BTB domain containing 7a / O95365*ENSMUSG0000003501118
Zbtb3 / Q91X45 / zinc finger and BTB domain containing 3 / Q9H5J0*ENSMUSG0000007166117
Zbtb10 / zinc finger and BTB domain containing 10 / Q96DT7*ENSMUSG0000006911416
Zbtb5 / Q7TQG0 / zinc finger and BTB domain containing 5 / O15062*ENSMUSG0000004965716
Q8BID6 / Zbtb46 / zinc finger and BTB domain containing 46 / Q86UZ6*ENSMUSG0000002758316
Q8VCZ7 / Zbtb7c / zinc finger and BTB domain containing 7C / A1YPR0*ENSMUSG0000004464616
Q811H0 / Zbtb42 / zinc finger and BTB domain containing 42 / B2RXF5*ENSMUSG0000003763816
Zbtb8b / zinc finger and BTB domain containing 8b / Q8NAP8* / AL033529.1*ENSMUSG0000004848516
Q9CWH1 / Zbtb8a / zinc finger and BTB domain containing 8a / Q96BR9*ENSMUSG0000002880714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hic2Gt(E225A08)Wrst/Hic2Gt(E225A08)Wrst
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0010770 preweaning lethality "death anytime between fertilization and weaning (Mus: approximately 3-4 weeks of age)" [MGI:Sanger_Karp "Submission from Natasha Karp"]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Allelic Composition: Hic2Gt(E225A08)Wrst/Hic2Gt(E225A08)Wrst
Genetic Background: involves: 129P2/OlaHsd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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