ENSMUSG00000063659


Mus musculus

Features
Gene ID: ENSMUSG00000063659
  
Biological name :Zbtb18
  
Synonyms : Q9WUK6 / Zbtb18 / zinc finger and BTB domain containing 18
  
Possible biological names infered from orthology : Q99592
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H4
Gene start: 177442351
Gene end: 177450764
  
Corresponding Affymetrix probe sets: 10352092 (MoGene1.0st)   1417010_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141663
Ensembl peptide - ENSMUSP00000141337
Ensembl peptide - ENSMUSP00000141673
Ensembl peptide - ENSMUSP00000142256
Ensembl peptide - ENSMUSP00000142124
Ensembl peptide - ENSMUSP00000142073
Ensembl peptide - ENSMUSP00000141901
Ensembl peptide - ENSMUSP00000141724
Ensembl peptide - ENSMUSP00000141694
Ensembl peptide - ENSMUSP00000076463
Ensembl peptide - ENSMUSP00000091831
NCBI entrez gene - 30928     See in Manteia.
MGI - MGI:1353609
RefSeq - XM_006496896
RefSeq - NM_001012330
RefSeq - NM_001355102
RefSeq - NM_001355103
RefSeq - NM_013915
RefSeq - XM_006496889
RefSeq - XM_006496890
RefSeq - XM_006496893
RefSeq - XM_006496894
RefSeq - XM_006496895
RefSeq Peptide - NP_038943
RefSeq Peptide - NP_001012330
RefSeq Peptide - NP_001342027
RefSeq Peptide - NP_001342028
RefSeq Peptide - NP_001342029
RefSeq Peptide - NP_001342030
RefSeq Peptide - NP_001342031
RefSeq Peptide - NP_001342032
swissprot - A0A0A6YWR6
swissprot - A0A1Y7VJC4
swissprot - A0A0A6YY33
swissprot - Q9WUK6
swissprot - A0A0A6YW03
swissprot - A0A0A6YXT0
swissprot - A0A0A6YXP2
swissprot - A0A0A6YX98
swissprot - A0A0A6YWT8
swissprot - H7BX69
Ensembl - ENSMUSG00000063659
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q1L8W0ENSDARG00000028228Danio rerio
 ZBTB18ENSGALG00000010705Gallus gallus
 Q99592ENSG00000179456Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q811H0 / Zbtb42 / zinc finger and BTB domain containing 42 / B2RXF5*ENSMUSG0000003763839
Zbtb3 / Q91X45 / zinc finger and BTB domain containing 3 / Q9H5J0*ENSMUSG0000007166135
Hic2 / Q9JLZ6 / Hypermethylated in cancer 2 protein / Q96JB3* / HIC ZBTB transcriptional repressor 2*ENSMUSG0000005024023
Q8BID6 / Zbtb46 / zinc finger and BTB domain containing 46 / Q86UZ6*ENSMUSG0000002758321
Zbtb5 / Q7TQG0 / zinc finger and BTB domain containing 5 / O15062*ENSMUSG0000004965721
Hic1 / HIC ZBTB transcriptional repressor 1 / Q14526*ENSMUSG0000004309921
Q64321 / Zbtb7b / zinc finger and BTB domain containing 7B / O15156*ENSMUSG0000002804220
O88939 / Zbtb7a / zinc finger and BTB domain containing 7a / O95365*ENSMUSG0000003501119
Q8VCZ7 / Zbtb7c / zinc finger and BTB domain containing 7C / A1YPR0*ENSMUSG0000004464619
Zbtb8b / zinc finger and BTB domain containing 8b / Q8NAP8* / AL033529.1*ENSMUSG0000004848518
Q9CWH1 / Zbtb8a / zinc finger and BTB domain containing 8a / Q96BR9*ENSMUSG0000002880716
Zbtb10 / zinc finger and BTB domain containing 10 / Q96DT7*ENSMUSG0000006911415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0051302 regulation of cell division IMP
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Zbtb18tm1.1Nda/Zbtb18tm1.1Nda,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb18tm1.1Nda/Zbtb18tm1.1Nda,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb18tm1.1Nda/Zbtb18tm1.1Nda,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Zbtb18tm1.1Nda/Zbtb18tm1.1Nda,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zbtb18tm2.1Haok/Zbtb18tm2.1Haok
Genetic Background: involves: 129

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

Allelic Composition: Zbtb18tm2.1Haok/Zbtb18tm2.1Haok
Genetic Background: involves: 129

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Zbtb18tm1.1Nda/Zbtb18tm1.1Nda,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008284 abnormal hippocampus pyramidal cell layer 
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008285 abnormal hippocampus granule cell layer 
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008440 abnormal subplate morphology "any strucutral anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
Show

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb18tm1.1Nda/Zbtb18tm1.1Nda,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Zbtb18tm2.1Haok/Zbtb18tm2.1Haok
Genetic Background: involves: 129

Allelic Composition: Zbtb18tm1Haok/Zbtb18tm1Haok
Genetic Background: involves: 129

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Zbtb18tm1.1Nda/Zbtb18tm1.1Nda,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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