ENSMUSG00000027583


Mus musculus

Features
Gene ID: ENSMUSG00000027583
  
Biological name :Zbtb46
  
Synonyms : Q8BID6 / Zbtb46 / zinc finger and BTB domain containing 46
  
Possible biological names infered from orthology : Q86UZ6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 181387762
Gene end: 181459426
  
Corresponding Affymetrix probe sets: 10490682 (MoGene1.0st)   1429168_at (Mouse Genome 430 2.0 Array)   1440489_at (Mouse Genome 430 2.0 Array)   1453856_at (Mouse Genome 430 2.0 Array)   1454884_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029106
Ensembl peptide - ENSMUSP00000084672
Ensembl peptide - ENSMUSP00000125584
Ensembl peptide - ENSMUSP00000137014
NCBI entrez gene - 72147     See in Manteia.
MGI - MGI:1919397
RefSeq - XM_017319271
RefSeq - NM_027656
RefSeq - NM_028125
RefSeq - XM_006500712
RefSeq - XM_006500713
RefSeq - XM_006500714
RefSeq - XM_006500715
RefSeq Peptide - NP_081932
RefSeq Peptide - NP_082401
swissprot - Q8BID6
swissprot - E0CZ94
Ensembl - ENSMUSG00000027583
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zbtb46ENSDARG00000078191Danio rerio
 ZBTB46ENSGALG00000006062Gallus gallus
 Q86UZ6ENSG00000130584Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zbtb10 / zinc finger and BTB domain containing 10 / Q96DT7*ENSMUSG0000006911431
Zbtb8b / zinc finger and BTB domain containing 8b / Q8NAP8* / AL033529.1*ENSMUSG0000004848525
Q9CWH1 / Zbtb8a / zinc finger and BTB domain containing 8a / Q96BR9*ENSMUSG0000002880722
Q9WUK6 / Zbtb18 / zinc finger and BTB domain containing 18 / Q99592*ENSMUSG0000006365918
O88939 / Zbtb7a / zinc finger and BTB domain containing 7a / O95365*ENSMUSG0000003501118
Hic1 / HIC ZBTB transcriptional repressor 1 / Q14526*ENSMUSG0000004309918
Hic2 / Q9JLZ6 / Hypermethylated in cancer 2 protein / Q96JB3* / HIC ZBTB transcriptional repressor 2*ENSMUSG0000005024017
Q64321 / Zbtb7b / zinc finger and BTB domain containing 7B / O15156*ENSMUSG0000002804216
Q8VCZ7 / Zbtb7c / zinc finger and BTB domain containing 7C / A1YPR0*ENSMUSG0000004464616
Q811H0 / Zbtb42 / zinc finger and BTB domain containing 42 / B2RXF5*ENSMUSG0000003763815
Zbtb5 / Q7TQG0 / zinc finger and BTB domain containing 5 / O15062*ENSMUSG0000004965714
Zbtb3 / Q91X45 / zinc finger and BTB domain containing 3 / Q9H5J0*ENSMUSG0000007166114


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030853 negative regulation of granulocyte differentiation IMP
 biological_processGO:0045650 negative regulation of macrophage differentiation IMP
 biological_processGO:0045656 negative regulation of monocyte differentiation IMP
 biological_processGO:2001199 negative regulation of dendritic cell differentiation IMP
 biological_processGO:2001200 positive regulation of dendritic cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Zbtb46tm2.1Mnz/Zbtb46tm2.1Mnz
Genetic Background: involves: C57BL/6

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
Show

Allelic Composition: Zbtb46tm2.1Mnz/Zbtb46tm2.1Mnz
Genetic Background: involves: C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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