ENSMUSG00000035011


Mus musculus

Features
Gene ID: ENSMUSG00000035011
  
Biological name :Zbtb7a
  
Synonyms : O88939 / Zbtb7a / zinc finger and BTB domain containing 7a
  
Possible biological names infered from orthology : O95365
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81135220
Gene end: 81152995
  
Corresponding Affymetrix probe sets: 10364984 (MoGene1.0st)   1437255_at (Mouse Genome 430 2.0 Array)   1450093_s_at (Mouse Genome 430 2.0 Array)   1452932_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113612
Ensembl peptide - ENSMUSP00000120987
Ensembl peptide - ENSMUSP00000114470
Ensembl peptide - ENSMUSP00000113787
Ensembl peptide - ENSMUSP00000047333
Ensembl peptide - ENSMUSP00000113428
NCBI entrez gene - 16969     See in Manteia.
MGI - MGI:1335091
RefSeq - XM_006513279
RefSeq - XM_006513282
RefSeq - XM_006513281
RefSeq - NM_010731
RefSeq - XM_006513280
RefSeq Peptide - NP_034861
swissprot - O88939
swissprot - D3Z4C3
swissprot - D3YVF8
swissprot - D3YZI8
Ensembl - ENSMUSG00000035011
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zbtb7aENSDARG00000039899Danio rerio
 O93567ENSGALG00000025907Gallus gallus
 O95365ENSG00000178951Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VCZ7 / Zbtb7c / zinc finger and BTB domain containing 7C / A1YPR0*ENSMUSG0000004464638
Q64321 / Zbtb7b / zinc finger and BTB domain containing 7B / O15156*ENSMUSG0000002804235
Hic2 / Q9JLZ6 / Hypermethylated in cancer 2 protein / Q96JB3* / HIC ZBTB transcriptional repressor 2*ENSMUSG0000005024020
Hic1 / HIC ZBTB transcriptional repressor 1 / Q14526*ENSMUSG0000004309920
Q8BID6 / Zbtb46 / zinc finger and BTB domain containing 46 / Q86UZ6*ENSMUSG0000002758319
Zbtb5 / Q7TQG0 / zinc finger and BTB domain containing 5 / O15062*ENSMUSG0000004965719
Q9WUK6 / Zbtb18 / zinc finger and BTB domain containing 18 / Q99592*ENSMUSG0000006365918
Zbtb3 / Q91X45 / zinc finger and BTB domain containing 3 / Q9H5J0*ENSMUSG0000007166117
Q811H0 / Zbtb42 / zinc finger and BTB domain containing 42 / B2RXF5*ENSMUSG0000003763815
Q9CWH1 / Zbtb8a / zinc finger and BTB domain containing 8a / Q96BR9*ENSMUSG0000002880714
Zbtb8b / zinc finger and BTB domain containing 8b / Q8NAP8* / AL033529.1*ENSMUSG0000004848514
Zbtb10 / zinc finger and BTB domain containing 10 / Q96DT7*ENSMUSG0000006911413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0051216 cartilage development NAS
 cellular_componentGO:0005634 nucleus NAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035035 histone acetyltransferase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb7atm1Ppp/Zbtb7atm2Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

Allelic Composition: Zbtb7atm1Ppp/Zbtb7atm2Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

Allelic Composition: Zbtb7atm1Ppp/Zbtb7atm2Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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