ENSMUSG00000028042


Mus musculus

Features
Gene ID: ENSMUSG00000028042
  
Biological name :Zbtb7b
  
Synonyms : Q64321 / Zbtb7b / zinc finger and BTB domain containing 7B
  
Possible biological names infered from orthology : O15156
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 89377644
Gene end: 89394776
  
Corresponding Affymetrix probe sets: 10499612 (MoGene1.0st)   1420663_at (Mouse Genome 430 2.0 Array)   1455071_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115425
Ensembl peptide - ENSMUSP00000103058
Ensembl peptide - ENSMUSP00000120641
Ensembl peptide - ENSMUSP00000123348
Ensembl peptide - ENSMUSP00000121498
Ensembl peptide - ENSMUSP00000029677
Ensembl peptide - ENSMUSP00000103055
Ensembl peptide - ENSMUSP00000103056
NCBI entrez gene - 22724     See in Manteia.
MGI - MGI:102755
RefSeq - XM_006501319
RefSeq - NM_001355206
RefSeq - NM_001355211
RefSeq - NM_009565
RefSeq - XM_006501313
RefSeq - XM_006501314
RefSeq - XM_006501316
RefSeq - XM_006501317
RefSeq - XM_006501318
RefSeq Peptide - NP_001342141
RefSeq Peptide - NP_033591
RefSeq Peptide - NP_001342135
RefSeq Peptide - NP_001342140
swissprot - D3YZR6
swissprot - Q5BJ24
swissprot - Q64321
swissprot - D3YXC8
swissprot - D3Z2X8
swissprot - D3Z0B5
Ensembl - ENSMUSG00000028042
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zbtb7bENSDARG00000021891Danio rerio
 ENSGALG00000041484Gallus gallus
 O15156ENSG00000160685Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VCZ7 / Zbtb7c / zinc finger and BTB domain containing 7C / A1YPR0*ENSMUSG0000004464640
O88939 / Zbtb7a / zinc finger and BTB domain containing 7a / O95365*ENSMUSG0000003501137
Hic1 / HIC ZBTB transcriptional repressor 1 / Q14526*ENSMUSG0000004309922
Hic2 / Q9JLZ6 / Hypermethylated in cancer 2 protein / Q96JB3* / HIC ZBTB transcriptional repressor 2*ENSMUSG0000005024022
Q9WUK6 / Zbtb18 / zinc finger and BTB domain containing 18 / Q99592*ENSMUSG0000006365919
Zbtb3 / Q91X45 / zinc finger and BTB domain containing 3 / Q9H5J0*ENSMUSG0000007166117
Q8BID6 / Zbtb46 / zinc finger and BTB domain containing 46 / Q86UZ6*ENSMUSG0000002758317
Zbtb5 / Q7TQG0 / zinc finger and BTB domain containing 5 / O15062*ENSMUSG0000004965717
Q811H0 / Zbtb42 / zinc finger and BTB domain containing 42 / B2RXF5*ENSMUSG0000003763816
Q9CWH1 / Zbtb8a / zinc finger and BTB domain containing 8a / Q96BR9*ENSMUSG0000002880715
Zbtb10 / zinc finger and BTB domain containing 10 / Q96DT7*ENSMUSG0000006911414
Zbtb8b / zinc finger and BTB domain containing 8b / Q8NAP8* / AL033529.1*ENSMUSG0000004848513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:2000320 negative regulation of T-helper 17 cell differentiation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gria4tm1Yfkk/Gria4tm1Yfkk
Genetic Background: B6.129S-Gria4tm1Yfkk

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: KitWads/Kit+
Genetic Background: C57BL/6J-KitWads

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl/Kitl+,Tg(PGK1-KITLG*220)441Daw/0
Genetic Background: involves: C3H

Allelic Composition: Tg(TcrAND)53Hed/?,Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7b+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb7btm1Itan/Zbtb7btm2Itan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Zbtb7btm2Itan/Zbtb7b+
Genetic Background: involves: 129 * C57BL/6

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd4tm2Litt/Cd4+,Zbtb7btm1Itan/Zbtb7btm1Tani
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Zbtb7btm1Litt/Zbtb7btm1.2Litt
Genetic Background: involves: C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm2Litt/Cd4+,Zbtb7btm1Tani/Zbtb7btm1Tani
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: KitWads/Kit+
Genetic Background: C57BL/6J-KitWads

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Zbtb7bhd/Zbtb7bhd
Genetic Background: involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd

Allelic Composition: Zbtb7btm2Litt/Zbtb7btm2Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lmnatm1Lgf/Lmnatm1Stw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Cd4tm2Litt/Cd4+,Zbtb7btm1Tani/Zbtb7btm1Tani
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Zbtb7btm1Itan/Zbtb7btm1Tani
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Zbtb7btm1Itan/Zbtb7btm2Itan
Genetic Background: involves: 129 * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zbtb7btm1Itan/Zbtb7btm1Tani
Genetic Background: involves: 129 * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb7btm1Itan/Zbtb7btm1Tani
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Zbtb7btm1Itan/Zbtb7btm2Itan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo
Genetic Background: Not Specified

Allelic Composition: Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7b+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Zbtb7btm1Litt/Zbtb7btm1.2Litt
Genetic Background: involves: C57BL/6

Allelic Composition: Zbtb7btm2Litt/Zbtb7btm1.2Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Zbtb7btm1.1Skok/Zbtb7btm1.1Skok
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb7bhpls/Zbtb7bhpls
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
Genetic Background: Not Specified

Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitWads/Kit+
Genetic Background: C57BL/6J-KitWads

 MP:0008077 abnormal CD8-positive T cell number "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo
Genetic Background: Not Specified

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitWads/Kit+
Genetic Background: C57BL/6J-KitWads

Allelic Composition: Zbtb7btm1Itan/Zbtb7btm1Tani
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Zbtb7btm1Itan/Zbtb7btm2Itan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Zbtb7btm1Litt/Zbtb7btm1.2Litt
Genetic Background: involves: C57BL/6

Allelic Composition: Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
Genetic Background: Not Specified

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
Genetic Background: involves: 129P2/OlaHsd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Runx1tm1Toku/Runx1tm1Toku,Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Cd4tm2Litt/Cd4+,Zbtb7btm1Itan/Zbtb7btm1Tani
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Zbtb7btm6.1Itan/Zbtb7btm6.1Itan,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Zbtb7btm1Litt/Zbtb7btm1.2Litt
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr