ENSG00000163904


Homo sapiens

Features
Gene ID: ENSG00000163904
  
Biological name :SENP2
  
Synonyms : Q9HC62 / SENP2 / SUMO1/sentrin/SMT3 specific peptidase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.2
Gene start: 185582496
Gene end: 185633551
  
Corresponding Affymetrix probe sets: 218122_s_at (Human Genome U133 Plus 2.0 Array)   222523_at (Human Genome U133 Plus 2.0 Array)   228380_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399201
Ensembl peptide - ENSP00000399156
Ensembl peptide - ENSP00000408114
Ensembl peptide - ENSP00000296257
Ensembl peptide - ENSP00000388893
Ensembl peptide - ENSP00000390229
Ensembl peptide - ENSP00000393197
NCBI entrez gene - 59343     See in Manteia.
OMIM - 608261
RefSeq - XM_017006973
RefSeq - NM_021627
RefSeq - XM_005247690
RefSeq - XM_005247691
RefSeq Peptide - NP_067640
swissprot - H7C1A0
swissprot - C9IYB7
swissprot - Q9HC62
swissprot - F8WCX8
swissprot - F8WED6
swissprot - F8WET6
swissprot - F8WED7
Ensembl - ENSG00000163904
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 senp2ENSDARG00000073837Danio rerio
 SENP2ENSGALG00000031128Gallus gallus
 Senp2ENSMUSG00000022855Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SENP1 / Q9P0U3 / SUMO1/sentrin specific peptidase 1ENSG0000007938736
SENP5 / Q96HI0 / SUMO1/sentrin specific peptidase 5ENSG0000011923121
SENP3 / Q9H4L4 / SUMO1/sentrin/SMT3 specific peptidase 3ENSG0000016195619
SENP3-EIF4A1 / SENP3-EIF4A1 readthrough (NMD candidate)ENSG0000027795717


Protein motifs (from Interpro)
Interpro ID Name
 IPR003653  Ulp1 protease family, C-terminal catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009950 dorsal/ventral axis specification IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0016926 protein desumoylation IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway NAS
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032875 regulation of DNA endoreduplication IEA
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051246 regulation of protein metabolic process IEA
 biological_processGO:0060707 trophoblast giant cell differentiation IEA
 biological_processGO:0060711 labyrinthine layer development IEA
 biological_processGO:0060712 spongiotrophoblast layer development IEA
 biological_processGO:1901797 negative regulation of signal transduction by p53 class mediator IEA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0004175 endopeptidase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0070139 SUMO-specific endopeptidase activity IDA
 molecular_functionGO:0070140 SUMO-specific isopeptidase activity IEA


Pathways (from Reactome)
Pathway description
SUMO is proteolytically processed


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction






 

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