ENSG00000079387


Homo sapiens

Features
Gene ID: ENSG00000079387
  
Biological name :SENP1
  
Synonyms : Q9P0U3 / SENP1 / SUMO1/sentrin specific peptidase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.11
Gene start: 48042898
Gene end: 48106308
  
Corresponding Affymetrix probe sets: 1552812_a_at (Human Genome U133 Plus 2.0 Array)   226619_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000447328
Ensembl peptide - ENSP00000448597
Ensembl peptide - ENSP00000450076
Ensembl peptide - ENSP00000394791
Ensembl peptide - ENSP00000447593
NCBI entrez gene - 29843     See in Manteia.
OMIM - 612157
RefSeq - XM_017019240
RefSeq - XM_017019235
RefSeq - XM_017019236
RefSeq - XM_017019237
RefSeq - XM_017019238
RefSeq - XM_017019239
RefSeq - NM_001267594
RefSeq - NM_001267595
RefSeq - XM_006719361
RefSeq - XM_006719362
RefSeq - XM_011538244
RefSeq - XM_011538245
RefSeq - XM_017019229
RefSeq - XM_017019230
RefSeq - XM_017019231
RefSeq - XM_017019232
RefSeq - XM_017019233
RefSeq - XM_017019234
RefSeq Peptide - NP_001254523
RefSeq Peptide - NP_001254524
swissprot - F8W0I8
swissprot - Q9P0U3
swissprot - F8VRZ8
Ensembl - ENSG00000079387
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-21c19.3ENSDARG00000078574Danio rerio
 Senp1ENSMUSG00000033075Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SENP2 / Q9HC62 / SUMO1/sentrin/SMT3 specific peptidase 2ENSG0000016390433
SENP5 / Q96HI0 / SUMO1/sentrin specific peptidase 5ENSG0000011923123
SENP3 / Q9H4L4 / SUMO1/sentrin/SMT3 specific peptidase 3ENSG0000016195619
SENP3-EIF4A1 / SENP3-EIF4A1 readthrough (NMD candidate)ENSG0000027795718


Protein motifs (from Interpro)
Interpro ID Name
 IPR003653  Ulp1 protease family, C-terminal catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0010724 regulation of definitive erythrocyte differentiation IEA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0016926 protein desumoylation IMP
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0097190 apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070139 SUMO-specific endopeptidase activity EXP
 molecular_functionGO:0070140 SUMO-specific isopeptidase activity ISS


Pathways (from Reactome)
Pathway description
SUMO is proteolytically processed


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction






 

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