Manteia - Molecule gene

ENSMUSG00000033075

Mus musculus

Features

Gene ID:	ENSMUSG00000033075

Biological name :	Senp1

Synonyms :	P59110 / Senp1 / Sentrin-specific protease 1

Possible biological names infered from orthology :	Q9P0U3 / SUMO1/sentrin specific peptidase 1

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	F1
Gene start:	98038744
Gene end:	98093744

Corresponding Affymetrix probe sets:	10432101 (MoGene1.0st) 1424330_at (Mouse Genome 430 2.0 Array) 1428925_at (Mouse Genome 430 2.0 Array) 1451319_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000046598 Ensembl peptide - ENSMUSP00000138032 Ensembl peptide - ENSMUSP00000138056 Ensembl peptide - ENSMUSP00000138394 NCBI entrez gene - 223870 See in Manteia. MGI - MGI:2445054 RefSeq - XM_006520884 RefSeq - NM_144851 RefSeq - XM_006520880 RefSeq - XM_006520881 RefSeq - XM_006520882 RefSeq - XM_006520883 RefSeq Peptide - NP_659100 swissprot - M0QWX4 swissprot - M0QWV7 swissprot - P59110 swissprot - S4R1V9 Ensembl - ENSMUSG00000033075

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:dkey-21c19.3	ENSDARG00000078574	Danio rerio
SENP1	ENSG00000079387	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Senp2 / Q91ZX6 / Mus musculus SUMO/sentrin specific peptidase 2 (Senp2), transcript variant 3, mRNA. / Q9HC62* / SUMO1/sentrin/SMT3 specific peptidase 2*	ENSMUSG00000022855	32
4930444G20Rik / RIKEN cDNA 4930444G20 gene	ENSMUSG00000069712	24
AF366264 / cDNA sequence AF366264	ENSMUSG00000057116	24
Gm5415	ENSMUSG00000091318	24
Senp5 / Q6NXL6 / Sentrin-specific protease 5 / Q96HI0* / SUMO1/sentrin specific peptidase 5*	ENSMUSG00000022772	22
Gm7275	ENSMUSG00000067716	20
Gm5407	ENSMUSG00000058176	19
Senp3 / Q9EP97 / Sentrin-specific protease 3 / Q9H4L4* / SENP3-EIF4A1* / SUMO1/sentrin/SMT3 specific peptidase 3* / SENP3-EIF4A1 readthrough (NMD candidate)*	ENSMUSG00000005204	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR003653	Ulp1 protease family, C-terminal catalytic domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0010724	regulation of definitive erythrocyte differentiation	IMP
biological_process	GO:0016926	protein desumoylation	IEA
biological_process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0097190	apoptotic signaling pathway	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005925	focal adhesion	IEA
cellular_component	GO:0031965	nuclear membrane	IEA
molecular_function	GO:0004175	endopeptidase activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008234	cysteine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0070139	SUMO-specific endopeptidase activity	ISO
molecular_function	GO:0070140	SUMO-specific isopeptidase activity	IMP

Pathways (from Reactome)

Pathway description

SUMO is proteolytically processed

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Coro1a^ptcd/Coro1a^tm1Achn Genetic Background: B6.Cg-Coro1a^ptcd Coro1a^tm1Achn Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0000259	abnormal vascular development	"malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0000313	abnormal cell death	"anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: B6.129S7-Rag1^tm1Mom
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Coro1a^ptcd/Coro1a^tm1Achn Genetic Background: B6.Cg-Coro1a^ptcd Coro1a^tm1Achn Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Tg(TcrAND)53Hed/?,Themis^tm1Gasc/Themis^tm1Gasc Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Ubiad1^tm1.1Thka/Ubiad1⁺ Genetic Background: C57BL/6-Ubiad1^tm1.1Thka Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Adipoq-cre)1Evdr/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Adipoq-cre)1Evdr
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ubiad1^tm1.1Thka/Ubiad1⁺ Genetic Background: C57BL/6-Ubiad1^tm1.1Thka Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Adipoq-cre)1Evdr/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Adipoq-cre)1Evdr
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Coro1a^ptcd/Coro1a^tm1Achn Genetic Background: B6.Cg-Coro1a^ptcd Coro1a^tm1Achn Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0001856	myocarditis	"inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0001869	pancreas inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: B6.129S7-Rag1^tm1Mom
MP:0002413	abnormal megakaryoblast morphology/development	"anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0002578	impaired ability to fire action potentials	"anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh Genetic Background: Not Specified
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: C57BL/6
MP:0002869	increased insulin autoantibody level	"elevated level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Coro1a^ptcd/Coro1a^tm1Achn Genetic Background: B6.Cg-Coro1a^ptcd Coro1a^tm1Achn
MP:0003059	decreased insulin secretion	"less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Adipoq-cre)1Evdr/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Adipoq-cre)1Evdr Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh Genetic Background: Not Specified Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: C57BL/6 Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh,Tg(Pdx1-cre/Esr1)#Dam/0 Genetic Background:* involves: C57BL/6
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0003562	abnormal beta cell physiology	"anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ubiad1^tm1.1Thka/Ubiad1⁺ Genetic Background: C57BL/6-Ubiad1^tm1.1Thka Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh Genetic Background: Not Specified Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: C57BL/6
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Coro1a^ptcd/Coro1a^tm1Achn Genetic Background: B6.Cg-Coro1a^ptcd Coro1a^tm1Achn
MP:0003858	enhanced coordination	"improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Senp1^{Gt(OST215108)Lex}/Senp1^{Gt(OST215108)Lex} Genetic Background: B6;129S5-Senp1^{Gt(OST215108)Lex}/Orl
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Coro1a^ptcd/Coro1a^tm1Achn Genetic Background: B6.Cg-Coro1a^ptcd Coro1a^tm1Achn
MP:0004803	increased susceptibility to autoimmune diabetes	"greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ubiad1^tm1.1Thka/Ubiad1⁺ Genetic Background: C57BL/6-Ubiad1^tm1.1Thka Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Adipoq-cre)1Evdr/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Adipoq-cre)1Evdr
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: C57BL/6 Allelic Composition: Senp1^tm1.1Eyeh/Senp1⁺,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: C57BL/6 Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh,Tg(Pdx1-cre/Esr1)#Dam/0 Genetic Background:* involves: C57BL/6
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0005563	abnormal hemoglobin content	"deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0008111	abnormal granulocyte differentiaton	"atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0008112	abnormal monocyte differentiation	"atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0008641	increased circulating interleukin-1 beta level	"increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0008713	abnormal cytokine level	"deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0008721	abnormal chemokine level	"deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0008803	abnormal placental labyrinth vasculature morphology	"any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: B6.129S7-Rag1^tm1Mom
MP:0008907	decreased total fat pad weight	"less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Coro1a^ptcd/Coro1a^tm1Achn Genetic Background: B6.Cg-Coro1a^ptcd Coro1a^tm1Achn Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0009115	abnormal fat cell morphology	"any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0009269	decreased fat cell size	"reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0009488	pancreatic islet cell apoptosis	"change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ubiad1^tm1.1Thka/Ubiad1⁺ Genetic Background: C57BL/6-Ubiad1^tm1.1Thka
MP:0010210	abnormal circulating cytokine level	"deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0010212	abnormal circulating C-reactive protein level	"deviation from the normal levels of the plasma protein that circulates in increased amounts during inflammation or after tissue damage and binds to phosphocholine expressed on the surface of dead or dying cells, including all types of pneumococci, in order to activate the complement system via the C1Q complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D12.776.034.145, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Senp1^{Gt(OST215108)Lex}/Senp1^{Gt(OST215108)Lex} Genetic Background: B6;129S5-Senp1^{Gt(OST215108)Lex}/Orl
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: B6.129S7-Rag1^tm1Mom Allelic Composition: Senp1^tm1.1Wami/Senp1^tm1.1Wami Genetic Background: involves: 129 * C57BL/6
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Coro1a^ptcd/Coro1a^tm1Achn Genetic Background: B6.Cg-Coro1a^ptcd Coro1a^tm1Achn
MP:0011941	increased fluid intake	"increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Fabp4-cre)#Abel/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Fabp4-cre)#Abel
MP:0014117	increased pancreatic beta cell apoptosis	"increase in the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]	Show Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami,Tg(Adipoq-cre)1Evdr/0 Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Adipoq-cre)1Evdr

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000026021	Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*	/ reaction
ENSMUSG00000020265	Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr