ENSMUSG00000022855


Mus musculus

Features
Gene ID: ENSMUSG00000022855
  
Biological name :Senp2
  
Synonyms : Mus musculus SUMO/sentrin specific peptidase 2 (Senp2), transcript variant 3, mRNA. / Q91ZX6 / Senp2
  
Possible biological names infered from orthology : Q9HC62 / SUMO1/sentrin/SMT3 specific peptidase 2
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B1
Gene start: 22009484
Gene end: 22049269
  
Corresponding Affymetrix probe sets: 10434645 (MoGene1.0st)   1425465_a_at (Mouse Genome 430 2.0 Array)   1425466_at (Mouse Genome 430 2.0 Array)   1451717_s_at (Mouse Genome 430 2.0 Array)   1455327_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023561
NCBI entrez gene - 75826     See in Manteia.
MGI - MGI:1923076
RefSeq - XM_006522690
RefSeq - NM_001357424
RefSeq - NM_029457
RefSeq - XM_006522688
RefSeq - XM_006522689
RefSeq Peptide - NP_001344353
RefSeq Peptide - NP_083733
swissprot - Q91ZX6
Ensembl - ENSMUSG00000022855
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 senp2ENSDARG00000073837Danio rerio
 SENP2ENSGALG00000031128Gallus gallus
 SENP2ENSG00000163904Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AF366264 / cDNA sequence AF366264ENSMUSG0000005711641
4930444G20Rik / RIKEN cDNA 4930444G20 geneENSMUSG0000006971241
Gm5415ENSMUSG0000009131840
Senp1 / P59110 / Sentrin-specific protease 1 / Q9P0U3* / SUMO1/sentrin specific peptidase 1*ENSMUSG0000003307535
Gm5407ENSMUSG0000005817628
Gm7275ENSMUSG0000006771628
Senp5 / Q6NXL6 / Sentrin-specific protease 5 / Q96HI0* / SUMO1/sentrin specific peptidase 5*ENSMUSG0000002277221
Senp3 / Q9EP97 / Sentrin-specific protease 3 / Q9H4L4* / SENP3-EIF4A1* / SUMO1/sentrin/SMT3 specific peptidase 3* / SENP3-EIF4A1 readthrough (NMD candidate)*ENSMUSG0000000520418


Protein motifs (from Interpro)
Interpro ID Name
 IPR003653  Ulp1 protease family, C-terminal catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009950 dorsal/ventral axis specification IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016926 protein desumoylation IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032875 regulation of DNA endoreduplication IMP
 biological_processGO:0035562 negative regulation of chromatin binding IMP
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051246 regulation of protein metabolic process IEA
 biological_processGO:0060707 trophoblast giant cell differentiation IMP
 biological_processGO:0060711 labyrinthine layer development IMP
 biological_processGO:0060712 spongiotrophoblast layer development IMP
 biological_processGO:1901797 negative regulation of signal transduction by p53 class mediator IDA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005643 nuclear pore ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0004175 endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0070139 SUMO-specific endopeptidase activity IEA
 molecular_functionGO:0070140 SUMO-specific isopeptidase activity IDA


Pathways (from Reactome)
Pathway description
SUMO is proteolytically processed


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001714 absent trophoblast cells "missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Scnn1btm1.1Hum/Scnn1btm1.1Hum
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scnn1btm1.1Hum/Scnn1btm1.1Hum
Genetic Background: involves: 129P2/OlaHsd

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scnn1btm1.1Hum/Scnn1btm1.1Hum
Genetic Background: involves: 129P2/OlaHsd

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Scnn1btm1.1Hum/Scnn1btm1.1Hum
Genetic Background: involves: 129P2/OlaHsd

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
Show

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0010637 sinus bradycardia "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm4Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

Allelic Composition: Senp2tm1Whsu/Senp2tm1Whsu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Senp2tm1Whsu/Senp2tm1Whsu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction






 

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