ENSG00000139372


Homo sapiens

Features
Gene ID: ENSG00000139372
  
Biological name :TDG
  
Synonyms : Q13569 / TDG / thymine DNA glycosylase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q23.3
Gene start: 103965804
Gene end: 103988874
  
Corresponding Affymetrix probe sets: 203742_s_at (Human Genome U133 Plus 2.0 Array)   203743_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445716
Ensembl peptide - ENSP00000439825
Ensembl peptide - ENSP00000445899
Ensembl peptide - ENSP00000266775
Ensembl peptide - ENSP00000376611
Ensembl peptide - ENSP00000390167
NCBI entrez gene - 6996     See in Manteia.
OMIM - 601423
RefSeq - XM_011538715
RefSeq - NM_003211
RefSeq - XM_005269125
RefSeq - XM_011538714
RefSeq Peptide - NP_003202
swissprot - B4E127
swissprot - H0YH18
swissprot - F5H0I7
swissprot - F5H539
swissprot - G8JL98
swissprot - Q13569
Ensembl - ENSG00000139372
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdg.1ENSDARG00000013004Danio rerio
 tdg.2ENSDARG00000086450Danio rerio
 TDGENSGALG00000031457Gallus gallus
 TdgENSMUSG00000034674Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003310  G/U mismatch-specific uracil/thymine-DNA glycosylase
 IPR005122  Uracil-DNA glycosylase-like
 IPR015637  G/U mismatch-specific DNA glycosylase
 IPR036895  Uracil-DNA glycosylase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006285 base-excision repair, AP site formation IMP
 biological_processGO:0006298 mismatch repair IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0035511 oxidative DNA demethylation TAS
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0045008 depyrimidination TAS
 biological_processGO:0080111 DNA demethylation IEA
 biological_processGO:1902544 regulation of DNA N-glycosylase activity IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding TAS
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0004844 uracil DNA N-glycosylase activity IDA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030983 mismatched DNA binding IDA
 molecular_functionGO:0031402 sodium ion binding IDA
 molecular_functionGO:0031404 chloride ion binding IDA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity IMP


Pathways (from Reactome)
Pathway description
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1
SUMOylation of DNA damage response and repair proteins
TET1,2,3 and TDG demethylate DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / reaction
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex






 

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