ENSMUSG00000034674


Mus musculus

Features
Gene ID: ENSMUSG00000034674
  
Biological name :Tdg
  
Synonyms : Mus musculus thymine DNA glycosylase (Tdg), transcript variant 3, mRNA. / P56581 / Tdg
  
Possible biological names infered from orthology : Q13569 / thymine DNA glycosylase
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 82629828
Gene end: 82650799
  
Corresponding Affymetrix probe sets: 10365230 (MoGene1.0st)   10368883 (MoGene1.0st)   10430871 (MoGene1.0st)   10564663 (MoGene1.0st)   1416790_a_at (Mouse Genome 430 2.0 Array)   1435715_x_at (Mouse Genome 430 2.0 Array)   1448462_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135883
Ensembl peptide - ENSMUSP00000135009
Ensembl peptide - ENSMUSP00000135621
Ensembl peptide - ENSMUSP00000089917
Ensembl peptide - ENSMUSP00000116707
Ensembl peptide - ENSMUSP00000121000
NCBI entrez gene - 21665     See in Manteia.
MGI - MGI:108247
RefSeq - XM_006513577
RefSeq - NM_001358517
RefSeq - NM_011561
RefSeq - NM_172552
RefSeq Peptide - NP_766140
RefSeq Peptide - NP_001345446
RefSeq Peptide - NP_035691
swissprot - H3BLR1
swissprot - H3BJJ4
swissprot - H3BL22
swissprot - P56581
swissprot - D3Z417
Ensembl - ENSMUSG00000034674
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdg.1ENSDARG00000013004Danio rerio
 tdg.2ENSDARG00000086450Danio rerio
 TDGENSGALG00000031457Gallus gallus
 TDGENSG00000139372Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003310  G/U mismatch-specific uracil/thymine-DNA glycosylase
 IPR005122  Uracil-DNA glycosylase-like
 IPR015637  G/U mismatch-specific DNA glycosylase
 IPR036895  Uracil-DNA glycosylase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006285 base-excision repair, AP site formation IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009790 embryo development IMP
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0035562 negative regulation of chromatin binding IDA
 biological_processGO:0040029 regulation of gene expression, epigenetic IMP
 biological_processGO:0080111 DNA demethylation IMP
 biological_processGO:1902544 regulation of DNA N-glycosylase activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016605 PML body IDA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0004844 uracil DNA N-glycosylase activity IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0031402 sodium ion binding IEA
 molecular_functionGO:0031404 chloride ion binding IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1
SUMOylation of DNA damage response and repair proteins
TET1,2,3 and TDG demethylate DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: MipCts/MipCts
Genetic Background: CTS/Shi

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Tdgtm2.1Abc/Tdgtm2.1Abc
Genetic Background: B6.129-Tdgtm2.1Abc

 MP:0009797 abnormal mismatch repair "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010500 myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Tdgtm2.1Abc/Tdgtm2.1Abc
Genetic Background: B6.129-Tdgtm2.1Abc

Allelic Composition: Tdgtm1Psch/Tdgtm1Psch
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex






 

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