ENSMUSG00000021911


Mus musculus

Features
Gene ID: ENSMUSG00000021911
  
Biological name :Parg
  
Synonyms : O88622 / Parg / Poly(ADP-ribose) glycohydrolase
  
Possible biological names infered from orthology : Q86W56
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 32201949
Gene end: 32297550
  
Corresponding Affymetrix probe sets: 10413853 (MoGene1.0st)   1448725_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128629
Ensembl peptide - ENSMUSP00000154704
Ensembl peptide - ENSMUSP00000132454
Ensembl peptide - ENSMUSP00000131566
Ensembl peptide - ENSMUSP00000130178
Ensembl peptide - ENSMUSP00000022470
Ensembl peptide - ENSMUSP00000127362
NCBI entrez gene - 26430     See in Manteia.
MGI - MGI:1347094
RefSeq - NM_011960
RefSeq - XM_011245071
RefSeq Peptide - NP_036090
swissprot - G3X8U8
swissprot - E9Q954
swissprot - O88622
swissprot - I6RAM3
swissprot - E9Q7T9
swissprot - E9Q3C4
swissprot - E9Q088
Ensembl - ENSMUSG00000021911
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pargaENSDARG00000061114Danio rerio
 PARGENSGALG00000002117Gallus gallus
 PARGENSG00000227345Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007724  Poly(ADP-ribose) glycohydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016045 detection of bacterium IMP
 biological_processGO:1990966 ATP generation from poly-ADP-D-ribose IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004649 poly(ADP-ribose) glycohydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / reaction






 

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