12649


Mus musculus (NCBI)
regulationcelldnaproteindamagemitoticcycleactivityphosphorylationbindingkinasecheckpointgprocessmtransitionproliferationrepairapoptoticresponsenucleustranscriptionintracellularsignaltransductionnuclearcentrosomeinvolvedhistoneh

Features
Gene ID: 12649
  
Biological name :
  
Synonyms : C85740|Chk1|rad27 / checkpoint kinase 1 / Chek1
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1420031_at (Mouse Genome 430 2.0 Array)   1420032_at (Mouse Genome 430 2.0 Array)   1439208_at (Mouse Genome 430 2.0 Array)   1449708_s_at (Mouse Genome 430 2.0 Array)   1450677_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 31542385
RefSeq - XP_017168606.1
RefSeq - NC_000075.6
RefSeq - 1039792015
RefSeq - NP_031717.2
RefSeq - NM_007691.5
RefSeq - XM_017313117.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000032113 to get all the annotations available for this gene.


Gene Ontology (GO)
response to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse to stresscell cyclecellular response to stimulusanatomical structure developmentdevelopmental growthnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell deathcellular component organizationbiosynthetic processresponse to abiotic stimuluscell communicationmicrotubule-based processresponse response to stresscell cyclcell cyclecellular cellular response to stimulusanatomicaanatomical structure developmentdevelopmedevelopmental growthnitrogen nitrogen compound metabolic processcellular cellular metabolic processprimary mprimary metabolic processorganic sorganic substance metabolic processcell deatcell deathcellular cellular component organizationbiosynthebiosynthetic processresponse response to abiotic stimuluscell commcell communicationmicrotubumicrotubule-based process
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic organic cyclic compound bindingheterocyclic coheterocyclic compound bindingsmall molecule small molecule bindingcatalytic activcatalytic activity, acting on a proteintransferase acttransferase activityprotein bindingprotein bindingion bindingion bindingcarbohydrate decarbohydrate derivative bindingdrug bindingdrug binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint ISO
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006975 DNA damage induced protein phosphorylation ISO
 biological_processGO:0006997 nucleus organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination ISO
 biological_processGO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IMP
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0045787 positive regulation of cell cycle ISO
 biological_processGO:0045839 negative regulation of mitotic nuclear division ISO
 biological_processGO:0046602 regulation of mitotic centrosome separation ISO
 biological_processGO:0048096 chromatin-mediated maintenance of transcription IMP
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint ISO
 biological_processGO:1902742 apoptotic process involved in development IMP
 biological_processGO:2000279 negative regulation of DNA biosynthetic process ISO
 biological_processGO:2000615 regulation of histone H3-K9 acetylation IDA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000794 condensed nuclear chromosome ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0035402 histone kinase activity (H3-T11 specific) ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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