Manteia

ENSDARG00000006782

Danio rerio

Features

Gene ID:	ENSDARG00000006782

Biological name :	rb1

Synonyms :	rb1 / retinoblastoma 1

Possible biological names infered from orthology :	P06400 / P13405 / RB transcriptional corepressor 1 / Retinoblastoma-associated protein

Species:	Danio rerio

Chr. number:	21
Strand:	-1
Band:
Gene start:	22960735
Gene end:	23017478

Corresponding Affymetrix probe sets:	Dr.20687.1.A1_at (Zebrafish Array) NM_001077780_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000021737 NCBI entrez gene - 777733 See in Manteia. RefSeq - NM_001077780 RefSeq Peptide - NP_001071248 swissprot - F1Q9D6 ZFIN ID - ZDB-GENE-040428-1 Ensembl - ENSDARG00000006782

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
rbl1 / retinoblastoma-like 1 (p107) / P28749* / RB transcriptional corepressor like 1*	ENSDARG00000008141	25
rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*	ENSDARG00000045636	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR002719	Retinoblastoma-associated protein, B-box
IPR002720	Retinoblastoma-associated protein, A-box
IPR013763	Cyclin-like
IPR015030	Retinoblastoma-associated protein, C-terminal
IPR024599	Retinoblastoma-associated protein, N-terminal
IPR028309	Retinoblastoma protein family
IPR033057	Retinoblastoma-associated protein

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0007601	visual perception	IMP
biological_process	GO:0008285	negative regulation of cell proliferation	IEA
biological_process	GO:0021554	optic nerve development	IMP
biological_process	GO:0031290	retinal ganglion cell axon guidance	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IEA
biological_process	GO:0051726	regulation of cell cycle	IEA
biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0035189	Rb-E2F complex	IEA
molecular_function	GO:0008134	transcription factor binding	IEA

Pathways (from Reactome)

Pathway description

Condensation of Prophase Chromosomes

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000008	brain	brain morphology , abnormal brain cell proliferation increased occurrence , abnormal brain neoplasm increased amount , abnormal	Show
ZFA:0000076	swim bladder	swim bladder flattened , abnormal	Show
ZFA:0000123	liver	liver increased size , abnormal	Show
ZFA:0000152	retina	retina retinal ganglion cell decreased amount , abnormal	Show
ZFA:0000435	cranial nerve II	cranial nerve II hypoplastic , abnormal	Show
ZFA:0001094	whole organism	whole organism lethal (sensu genetics) , abnormal whole organism viability , abnormal whole organism movement behavioral quality , abnormal whole organism decreased life span , abnormal	Show
ZFA:0001114	head	head malformed , abnormal	Show
ZFA:0001117	post-vent region	post-vent region movement quality , abnormal	Show
ZFA:0009091	melanocyte	melanocyte area , abnormal	Show
ZFA:0009310	retinal ganglion cell	retinal ganglion cell axon morphology , abnormal retinal ganglion cell axon misrouted , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr