ENSGALG00000016997


Gallus gallus

Features
Gene ID: ENSGALG00000016997
  
Biological name :RB1
  
Synonyms : RB1 / retinoblastoma-associated protein
  
Possible biological names infered from orthology : P06400 / P13405 / RB transcriptional corepressor 1
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 168747566
Gene end: 168831538
  
Corresponding Affymetrix probe sets: Gga.2986.2.S1_a_at (Chicken Array)   Gga.2986.3.A1_at (Chicken Array)   Gga.2986.3.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000035704
Ensembl peptide - ENSGALP00000063247
Ensembl peptide - ENSGALP00000062644
NCBI entrez gene - 386582     See in Manteia.
RefSeq - NM_204419
RefSeq Peptide - NP_989750
swissprot - A0A1L1RWN6
swissprot - A0A1L1RUY7
swissprot - F1NAY3
Ensembl - ENSGALG00000016997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rb1ENSDARG00000006782Danio rerio
 RB1ENSG00000139687Homo sapiens
 Rb1ENSMUSG00000022105Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBL1 / RB transcriptional corepressor like 1 / P28749* / Q64701* / Retinoblastoma-like protein 1 *ENSGALG0000000133226
RBL2 / Q08999* / Q64700* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*ENSGALG0000000366326


Protein motifs (from Interpro)
Interpro ID Name
 IPR002719  Retinoblastoma-associated protein, B-box
 IPR002720  Retinoblastoma-associated protein, A-box
 IPR013763  Cyclin-like
 IPR015030  Retinoblastoma-associated protein, C-terminal
 IPR024599  Retinoblastoma-associated protein, N-terminal
 IPR028309  Retinoblastoma protein family
 IPR033057  Retinoblastoma-associated protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001894 tissue homeostasis IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0031134 sister chromatid biorientation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0034088 maintenance of mitotic sister chromatid cohesion IEA
 biological_processGO:0034349 glial cell apoptotic process IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0042551 neuron maturation IEA
 biological_processGO:0043353 enucleate erythrocyte differentiation IEA
 biological_processGO:0043550 regulation of lipid kinase activity IEA
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045842 positive regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048667 cell morphogenesis involved in neuron differentiation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071459 protein localization to chromosome, centromeric region IEA
 biological_processGO:0071466 cellular response to xenobiotic stimulus IEA
 biological_processGO:0071922 regulation of cohesin loading IEA
 biological_processGO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0035189 Rb-E2F complex IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0061676 importin-alpha family protein binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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