ENSG00000172059


Homo sapiens

Features
Gene ID: ENSG00000172059
  
Biological name :KLF11
  
Synonyms : KLF11 / Kruppel like factor 11 / O14901
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p25.1
Gene start: 10042849
Gene end: 10054836
  
Corresponding Affymetrix probe sets: 1553137_s_at (Human Genome U133 Plus 2.0 Array)   218486_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442722
Ensembl peptide - ENSP00000386058
Ensembl peptide - ENSP00000444690
Ensembl peptide - ENSP00000387866
Ensembl peptide - ENSP00000388263
Ensembl peptide - ENSP00000307023
NCBI entrez gene - 8462     See in Manteia.
OMIM - 603301
RefSeq - NM_001177716
RefSeq - NM_001177718
RefSeq - NM_003597
RefSeq Peptide - NP_001171187
RefSeq Peptide - NP_001171189
RefSeq Peptide - NP_003588
swissprot - Q53QU8
swissprot - C9JM94
swissprot - B5MCC4
swissprot - O14901
swissprot - E7EX78
Ensembl - ENSG00000172059
  
Related genetic diseases (OMIM): 610508 - Maturity-onset diabetes of the young, type VII, 610508

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf11aENSDARG00000030844Danio rerio
 klf11bENSDARG00000013794Danio rerio
 KLF11ENSGALG00000016440Gallus gallus
 Klf11ENSMUSG00000020653Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLF10 / Q13118 / Kruppel like factor 10ENSG0000015509035
SP1 / P08047 / Sp1 transcription factorENSG0000018559122
SP3 / Q02447 / Sp3 transcription factorENSG0000017284521
SP4 / Q02446 / Sp4 transcription factorENSG0000010586621
SP2 / Q02086 / Sp2 transcription factorENSG0000016718221
KLF14 / Kruppel like factor 14ENSG0000026626520
SP8 / Q8IXZ3 / Sp8 transcription factorENSG0000016465119
SP9 / P0CG40 / Sp9 transcription factorENSG0000021723618
SP7 / Q8TDD2 / Sp7 transcription factorENSG0000017037418
KLF13 / Q9Y2Y9 / Kruppel like factor 13ENSG0000016992618
SP5 / Q6BEB4 / Sp5 transcription factorENSG0000020433517
KLF16 / Q9BXK1 / Kruppel like factor 16ENSG0000012991117
KLF9 / Q13886 / Kruppel like factor 9ENSG0000011913816
SP6 / Q3SY56 / Sp6 transcription factorENSG0000018912016


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:1901653 cellular response to peptide IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0004904 Insulin-dependent maturity-onset diabetes of the young 
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 HP:0005978 Noninsulin-dependent diabetes mellitus 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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