ENSG00000172845


Homo sapiens

Features
Gene ID: ENSG00000172845
  
Biological name :SP3
  
Synonyms : Q02447 / SP3 / Sp3 transcription factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q31.1
Gene start: 173906459
Gene end: 173965702
  
Corresponding Affymetrix probe sets: 213168_at (Human Genome U133 Plus 2.0 Array)   227537_s_at (Human Genome U133 Plus 2.0 Array)   229217_at (Human Genome U133 Plus 2.0 Array)   232529_at (Human Genome U133 Plus 2.0 Array)   238035_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000310301
Ensembl peptide - ENSP00000406140
Ensembl peptide - ENSP00000413665
Ensembl peptide - ENSP00000492253
NCBI entrez gene - 6670     See in Manteia.
OMIM - 601804
RefSeq - NM_001017371
RefSeq - NM_003111
RefSeq - NM_001172712
RefSeq Peptide - NP_001017371
RefSeq Peptide - NP_003102
RefSeq Peptide - NP_001166183
swissprot - Q02447
swissprot - H0Y6K5
swissprot - H0Y7L6
Ensembl - ENSG00000172845
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp3aENSDARG00000001549Danio rerio
 sp3bENSDARG00000007812Danio rerio
 SP3ENSGALG00000031796Gallus gallus
 Sp3ENSMUSG00000027109Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SP4 / Q02446 / Sp4 transcription factorENSG0000010586638
SP1 / P08047 / Sp1 transcription factorENSG0000018559136
SP2 / Q02086 / Sp2 transcription factorENSG0000016718225
SP8 / Q8IXZ3 / Sp8 transcription factorENSG0000016465119
SP9 / P0CG40 / Sp9 transcription factorENSG0000021723618
SP5 / Q6BEB4 / Sp5 transcription factorENSG0000020433518
SP7 / Q8TDD2 / Sp7 transcription factorENSG0000017037417
KLF11 / O14901 / Kruppel like factor 11ENSG0000017205914
SP6 / Q3SY56 / Sp6 transcription factorENSG0000018912014
KLF10 / Q13118 / Kruppel like factor 10ENSG0000015509012
KLF14 / Kruppel like factor 14ENSG0000026626510
KLF16 / Q9BXK1 / Kruppel like factor 16ENSG0000012991110
KLF13 / Q9Y2Y9 / Kruppel like factor 13ENSG0000016992610
KLF9 / Q13886 / Kruppel like factor 9ENSG0000011913810


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR030452  Transcription factor Sp3
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001779 natural killer cell differentiation IEA
 biological_processGO:0001829 trophectodermal cell differentiation IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030219 megakaryocyte differentiation IEA
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030851 granulocyte differentiation IEA
 biological_processGO:0043353 enucleate erythrocyte differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0060136 embryonic process involved in female pregnancy IEA
 biological_processGO:0060216 definitive hemopoiesis IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0032993 protein-DNA complex ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex






 

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