ENSMUSG00000061809


Mus musculus

Features
Gene ID: ENSMUSG00000061809
  
Biological name :Tbpl2
  
Synonyms : Q6SJ95 / TATA box-binding protein-like protein 2 / Tbpl2
  
Possible biological names infered from orthology : Q6SJ96 / TATA-box binding protein like 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 24071721
Gene end: 24096595
  
Corresponding Affymetrix probe sets: 10480468 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000079309
Ensembl peptide - ENSMUSP00000120310
NCBI entrez gene - 227606     See in Manteia.
MGI - MGI:2684058
RefSeq - NM_199059
RefSeq - NM_001289689
RefSeq Peptide - NP_001276618
RefSeq Peptide - NP_951014
swissprot - Q6SJ95
swissprot - Z4YMT0
Ensembl - ENSMUSG00000061809
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbpl2ENSDARG00000097302Danio rerio
 TBPL2ENSGALG00000012145Gallus gallus
 TBPL2ENSG00000182521Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbp / P29037 / TATA box binding protein / P20226*ENSMUSG0000001476749
Tbpl1 / P62340 / TATA box-binding protein-like protein 1 / P62380* / TATA-box binding protein like 1*ENSMUSG0000007135921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000814  TATA-box binding protein
 IPR030491  TATA-box binding protein, conserved site
 IPR033710  TATA-box binding protein, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0003697 absent zona pellucida "missing the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0009093 oocyte degeneration "a retrogressive impairment of function or destruction of the female germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0009362 abnormal primary ovarian follicle morphology "any structural abnormality in the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0009364 abnormal mature ovarian follicle morphology "any structural abnormality in the ovarian follicle that is ready for ovulation and presents a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0009444 ovarian follicular cyst "a sac filled with fluid that may develop when the structure containing the egg fails to break open at the time of ovulation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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