ENSMUSG00000071359


Mus musculus

Features
Gene ID: ENSMUSG00000071359
  
Biological name :Tbpl1
  
Synonyms : P62340 / TATA box-binding protein-like protein 1 / Tbpl1
  
Possible biological names infered from orthology : P62380 / TATA-box binding protein like 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A3
Gene start: 22703879
Gene end: 22731938
  
Corresponding Affymetrix probe sets: 10368229 (MoGene1.0st)   1431415_a_at (Mouse Genome 430 2.0 Array)   1434907_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093470
Ensembl peptide - ENSMUSP00000114223
NCBI entrez gene - 237336     See in Manteia.
MGI - MGI:1339946
RefSeq - XM_006512730
RefSeq - NM_011603
RefSeq Peptide - NP_035733
swissprot - P62340
Ensembl - ENSMUSG00000071359
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbpl1ENSDARG00000036868Danio rerio
 TBPL1ENSGALG00000013981Gallus gallus
 TBPL1ENSG00000028839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbp / P29037 / TATA box binding protein / P20226*ENSMUSG0000001476739
Tbpl2 / Q6SJ95 / TATA box-binding protein-like protein 2 / Q6SJ96* / TATA-box binding protein like 2*ENSMUSG0000006180939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000814  TATA-box binding protein
 IPR015445  TATA-Box binding protein-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001675 acrosome assembly IMP
 biological_processGO:0006235 dTTP biosynthetic process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0007289 spermatid nucleus differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005672 transcription factor TFIIA complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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