ENSMUSG00000047861


Mus musculus

Features
Gene ID: ENSMUSG00000047861
  
Biological name :Foxi1
  
Synonyms : Forkhead box protein I1 / Foxi1 / Q922I5
  
Possible biological names infered from orthology : forkhead box I1 / Q12951
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A4
Gene start: 34204338
Gene end: 34208089
  
Corresponding Affymetrix probe sets: 10385114 (MoGene1.0st)   1449458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058651
NCBI entrez gene - 14233     See in Manteia.
MGI - MGI:1096329
RefSeq - NM_023907
RefSeq Peptide - NP_076396
swissprot - Q922I5
Ensembl - ENSMUSG00000047861
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxi3aENSDARG00000055926Danio rerio
 foxi3bENSDARG00000009550Danio rerio
 FOXI1ENSGALG00000002105Gallus gallus
 FOXI1ENSG00000168269Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxi3 / forkhead box I3 / A8MTJ6*ENSMUSG0000005587444
Foxi2 / forkhead box I2 / Q6ZQN5*ENSMUSG0000004837737
Foxa2 / P35583 / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA. / Q9Y261* / forkhead box A2*ENSMUSG0000003702527
Foxc1 / Q61572 / Forkhead box protein C1 / Q12948* / forkhead box C1*ENSMUSG0000005029527
Foxc2 / Q61850 / Forkhead box protein C2 / Q99958* / forkhead box C2*ENSMUSG0000004671426
Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*ENSMUSG0000003545124
Foxl2 / O88470 / Forkhead box protein L2 / P58012* / forkhead box L2*ENSMUSG0000005039723
Foxl1 / Q64731 / Forkhead box protein L1 / Q12952* / forkhead box L1*ENSMUSG0000009708422
Foxa3 / P35584 / Hepatocyte nuclear factor 3-gamma / P55318* / forkhead box A3*ENSMUSG0000004089122
Foxs1 / Q61574 / Forkhead box protein S1 / O43638* / forkhead box S1*ENSMUSG0000007467621
Foxb1 / Q64732 / Forkhead box protein B1 / Q99853* / forkhead box B1*ENSMUSG0000005924618
Foxb2 / Q64733 / Forkhead box protein B2 / Q5VYV0* / forkhead box B2*ENSMUSG0000005682918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR033065  Forkhead box protein I1
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0000035 abnormal membranous labyrinth "malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0002978 absent otoliths "absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0003147 absent cochlea "absence or agenesis of the cochlea" [J:23837, J:36834, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0003226 absent modiolus "absence of the central conical bony pillar of the cochlea" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:82307]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0004314 absent vestibule "absence of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0004316 enlarged saccule "enlarged size of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0004335 enlarged utricle "increased size of the larger of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0004410 absent endocochlear potential "absence of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea, indicating a primary defect in fluid homeostasis of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0004922 abnormal common crus morphology "any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0004928 increased epididymis weight "increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0005272 abnormal temporal bone morphology "anomalous structure of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0006012 dilated endolymphatic duct "an expansion in the volume of the endolymphatic duct" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0006014 dilated endolymphatic sac "an expansion in the volume of the endolymphatic sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0006015 dilated lateral semicircular canal "an expansion in the volume of the lateral semicircular canal" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0006016 dilated posterior semicircular canal "an expansion in the volume of the posterior semicircular canal" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:67072:]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0006287 inner ear cysts "abnormal membranous sacs in any component of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:111415, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Bcl2l11tm1.1Ast/Bcl2l11+
Genetic Background: B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Ast

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1tm1Sven
Genetic Background: involves: CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr