ENSMUSG00000040891


Mus musculus

Features
Gene ID: ENSMUSG00000040891
  
Biological name :Foxa3
  
Synonyms : Foxa3 / Hepatocyte nuclear factor 3-gamma / P35584
  
Possible biological names infered from orthology : forkhead box A3 / P55318
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19013284
Gene end: 19023538
  
Corresponding Affymetrix probe sets: 10560431 (MoGene1.0st)   1431900_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043173
NCBI entrez gene - 15377     See in Manteia.
MGI - MGI:1347477
RefSeq - NM_008260
RefSeq Peptide - NP_032286
swissprot - P35584
Ensembl - ENSMUSG00000040891
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxa3ENSDARG00000012788Danio rerio
 FOXA3ENSG00000170608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*ENSMUSG0000003545153
Foxa2 / P35583 / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA. / Q9Y261* / forkhead box A2*ENSMUSG0000003702548
Foxb1 / Q64732 / Forkhead box protein B1 / Q99853* / forkhead box B1*ENSMUSG0000005924629
Foxc1 / Q61572 / Forkhead box protein C1 / Q12948* / forkhead box C1*ENSMUSG0000005029529
Foxc2 / Q61850 / Forkhead box protein C2 / Q99958* / forkhead box C2*ENSMUSG0000004671428
Foxb2 / Q64733 / Forkhead box protein B2 / Q5VYV0* / forkhead box B2*ENSMUSG0000005682927
Foxi3 / forkhead box I3 / A8MTJ6*ENSMUSG0000005587425
Foxi1 / Q922I5 / Forkhead box protein I1 / Q12951* / forkhead box I1*ENSMUSG0000004786123
Foxl1 / Q64731 / Forkhead box protein L1 / Q12952* / forkhead box L1*ENSMUSG0000009708422
Foxi2 / forkhead box I2 / Q6ZQN5*ENSMUSG0000004837722
Foxs1 / Q61574 / Forkhead box protein S1 / O43638* / forkhead box S1*ENSMUSG0000007467620
Foxl2 / O88470 / Forkhead box protein L2 / P58012* / forkhead box L2*ENSMUSG0000005039720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR013638  Fork-head N-terminal
 IPR018122  Fork head domain conserved site1
 IPR018533  Forkhead box protein, C-terminal
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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