ENSDARG00000012788


Danio rerio

Features
Gene ID: ENSDARG00000012788
  
Biological name :foxa3
  
Synonyms : forkhead box A3 / foxa3
  
Possible biological names infered from orthology : Hepatocyte nuclear factor 3-gamma / P35584 / P55318
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 46350574
Gene end: 46354269
  
Corresponding Affymetrix probe sets: Dr.1307.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000006410
swissprot - Q1LV18
ZFIN ID - ZDB-GENE-980526-423
Ensembl - ENSDARG00000012788
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXA3ENSG00000170608Homo sapiens
 Foxa3ENSMUSG00000040891Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
foxa1 / forkhead box A1ENSDARG0000010213846
foxa2 / forkhead box A2 / P35583* / Q9Y261* / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA.*ENSDARG0000000341144
foxa / forkhead box A sequenceENSDARG0000008709430
Q9DE25 / foxc1a / forkhead box C1a / FOXC1* / Q12948* / Q61572* / forkhead box C1* / Forkhead box protein C1 *ENSDARG0000009148124
foxb1a / forkhead box B1a / FOXB1* / Q64732* / Q99853* / forkhead box B1* / Forkhead box protein B1 *ENSDARG0000008904223
Q9DE24 / foxc1b / forkhead box C1b / FOXC1* / Q12948* / Q61572* / forkhead box C1* / Forkhead box protein C1 *ENSDARG0000005539823
foxb1b / forkhead box B1b / FOXB1* / Q64732* / Q99853* / forkhead box B1* / Forkhead box protein B1 *ENSDARG0000005365023
foxb2 / forkhead box B2 / Q5VYV0* / Q64733* / Forkhead box protein B2 *ENSDARG0000003747522
foxi2 / forkhead box I2 / FOXI3* / Q6ZQN5* / A8MTJ6* / forkhead box I3*ENSDARG0000006971520
foxi1 / forkhead box i1ENSDARG0000010456620
foxi3b / forkhead box I3b / FOXI1* / Q12951* / Q922I5* / forkhead box I1* / Forkhead box protein I1 *ENSDARG0000000955019
foxi3a / forkhead box I3a / FOXI1* / Q12951* / Q922I5* / forkhead box I1* / Forkhead box protein I1 *ENSDARG0000005592618
foxl1 / forkhead box L1 / Q12952* / Q64731* / Forkhead box protein L1 *ENSDARG0000000813317
foxl2a / forkhead box L2a / FOXL2* / O88470* / P58012* / forkhead box L2* / Forkhead box protein L2 *ENSDARG0000004218016
zgc:194189ENSDARG0000000801015
foxl2b / forkhead box L2b / FOXL2* / P58012* / forkhead box L2*ENSDARG0000006841715


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR013638  Fork-head N-terminal
 IPR018122  Fork head domain conserved site1
 IPR018533  Forkhead box protein, C-terminal
 IPR030456  Fork head domain conserved site 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007420 brain development IGI
 biological_processGO:0021999 neural plate anterior/posterior regionalization IGI
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0033504 floor plate development IMP
 biological_processGO:0048319 axial mesoderm morphogenesis IMP
 biological_processGO:0048785 hatching gland development IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000004 anterior axial hypoblast anterior axial hypoblast morphology , abnormal
Show

 ZFA:0000022 floor plate floor plate decreased length , abnormal
floor plate disorganized , abnormal
floor plate cell elongated , abnormal
Show

 ZFA:0000026 hatching gland hatching gland aplastic , abnormal
Show

 ZFA:0000031 hypochord hypochord decreased length , abnormal
hypochord disorganized , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate poorly differentiated , abnormal
Show

 ZFA:0000077 tail bud tail bud morphology , abnormal
Show

 ZFA:0000091 axial chorda mesoderm axial chorda mesoderm decreased width , abnormal
axial chorda mesoderm aplastic , abnormal
Show

 ZFA:0000135 notochord notochord disorganized , abnormal
notochord cell decreased size , abnormal
notochord cell mislocalised , abnormal
Show

 ZFA:0000155 somite somite fused with somite , abnormal
Show

 ZFA:0000164 ventral mesenchyme ventral mesenchyme distended , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm increased area , abnormal
Show

 ZFA:0001670 notochord posterior region notochord posterior region truncated , abnormal
Show

 ZFA:0009094 goblet cell goblet cell cell maturation disrupted , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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