ENSDARG00000091481


Danio rerio

Features
Gene ID: ENSDARG00000091481
  
Biological name :foxc1a
  
Synonyms : forkhead box C1a / foxc1a / Q9DE25
  
Possible biological names infered from orthology : forkhead box C1 / Forkhead box protein C1 / FOXC1 / Q12948 / Q61572
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 686873
Gene end: 689047
  
Corresponding Affymetrix probe sets: Dr.15719.1.S1_at (Zebrafish Array)   NM_131728_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000105372
NCBI entrez gene - 100148408     See in Manteia.
RefSeq - NM_131728
RefSeq Peptide - NP_571803
swissprot - Q9DE25
ZFIN ID - ZDB-GENE-010302-1
Ensembl - ENSDARG00000091481
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXC1ENSG00000054598Homo sapiens
 Foxc1ENSMUSG00000050295Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DE24 / foxc1b / forkhead box C1b / FOXC1* / Q12948* / Q61572* / forkhead box C1* / Forkhead box protein C1 *ENSDARG0000005539865
foxa / forkhead box A sequenceENSDARG0000008709422
foxa3 / forkhead box A3 / P35584* / P55318* / Hepatocyte nuclear factor 3-gamma *ENSDARG0000001278822
foxa1 / forkhead box A1ENSDARG0000010213822
foxa2 / forkhead box A2 / P35583* / Q9Y261* / Mus musculus forkhead box A2 (Foxa2), transcript variant 3, mRNA.*ENSDARG0000000341122
foxl1 / forkhead box L1 / Q12952* / Q64731* / Forkhead box protein L1 *ENSDARG0000000813321
foxi2 / forkhead box I2 / FOXI3* / Q6ZQN5* / A8MTJ6* / forkhead box I3*ENSDARG0000006971520
foxl2a / forkhead box L2a / FOXL2* / O88470* / P58012* / forkhead box L2* / Forkhead box protein L2 *ENSDARG0000004218020
foxi3b / forkhead box I3b / FOXI1* / Q12951* / Q922I5* / forkhead box I1* / Forkhead box protein I1 *ENSDARG0000000955020
foxi1 / forkhead box i1ENSDARG0000010456620
foxb1b / forkhead box B1b / FOXB1* / Q64732* / Q99853* / forkhead box B1* / Forkhead box protein B1 *ENSDARG0000005365019
foxb1a / forkhead box B1a / FOXB1* / Q64732* / Q99853* / forkhead box B1* / Forkhead box protein B1 *ENSDARG0000008904219
foxi3a / forkhead box I3a / FOXI1* / Q12951* / Q922I5* / forkhead box I1* / Forkhead box protein I1 *ENSDARG0000005592618
foxl2b / forkhead box L2b / FOXL2* / P58012* / forkhead box L2*ENSDARG0000006841718
zgc:194189ENSDARG0000000801017
foxb2 / forkhead box B2 / Q5VYV0* / Q64733* / Forkhead box protein B2 *ENSDARG0000003747517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001755 neural crest cell migration IGI
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0030325 adrenal gland development IGI
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0039021 pronephric glomerulus development IGI
 biological_processGO:0040036 regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0043114 regulation of vascular permeability IGI
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0061300 cerebellum vasculature development IGI
 biological_processGO:0061386 closure of optic fissure IMP
 biological_processGO:0072015 glomerular visceral epithelial cell development IMP
 biological_processGO:0072149 glomerular visceral epithelial cell fate commitment IGI
 biological_processGO:1902366 regulation of Notch signaling pathway involved in somitogenesis IMP
 biological_processGO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
Show

 ZFA:0000012 central nervous system central nervous system hemorrhagic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye hemorrhagic , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000155 somite somite decreased height , abnormal
somite decreased size , abnormal
somite decreased amount , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm Notch signaling pathway decreased process quality , abnormal
paraxial mesoderm fibroblast growth factor receptor signaling pathway decreased process quality , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased mobility , abnormal
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 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased amount , abnormal
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 ZFA:0001320 endocardium endocardium morphology , abnormal
endocardium decreased size , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus physical object quality , abnormal
pronephric glomerulus lacks all parts of type pronephric glomerular capillary , abnormal
pronephric glomerulus lacks all parts of type pronephric podocyte slit diaphragm, abnormal
Show

 ZFA:0001673 pronephric podocyte pronephric podocyte decreased amount , abnormal
pronephric podocyte cell projection malformed , abnormal
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 ZFA:0005436 pectoral fin nerve pectoral fin nerve neuromuscular junction decreased amount , abnormal
pectoral fin nerve axon terminus decreased amount , abnormal
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 ZFA:0005439 pectoral fin motor nerve 1 pectoral fin motor nerve 1 motor neuron axon guidance process quality , abnormal
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 ZFA:0005440 pectoral fin motor nerve 2 pectoral fin motor nerve 2 motor neuron axon guidance process quality , abnormal
pectoral fin motor nerve 2 axon defasciculated , abnormal
pectoral fin motor nerve 2 axon terminus mislocalised , abnormal
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 ZFA:0005441 pectoral fin motor nerve 3 pectoral fin motor nerve 3 motor neuron axon guidance process quality , abnormal
pectoral fin motor nerve 3 axon defasciculated , abnormal
pectoral fin motor nerve 3 axon terminus mislocalised , abnormal
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 ZFA:0005450 pectoral fin motor nerve 4 pectoral fin motor nerve 4 axon decreased branchiness , abnormal
pectoral fin motor nerve 4 motor neuron axon guidance process quality , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron axon guidance process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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