ENSG00000124766


Homo sapiens

Features
Gene ID: ENSG00000124766
  
Biological name :SOX4
  
Synonyms : Q06945 / SOX4 / SRY-box 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.3
Gene start: 21592768
Gene end: 21598619
  
Corresponding Affymetrix probe sets: 1567906_at (Human Genome U133 Plus 2.0 Array)   201416_at (Human Genome U133 Plus 2.0 Array)   201417_at (Human Genome U133 Plus 2.0 Array)   201418_s_at (Human Genome U133 Plus 2.0 Array)   213668_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000244745
NCBI entrez gene - 6659     See in Manteia.
OMIM - 184430
RefSeq - NM_003107
RefSeq Peptide - NP_003098
swissprot - Q06945
Ensembl - ENSG00000124766
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox4aENSDARG00000004588Danio rerio
 sox4bENSDARG00000098834Danio rerio
 SOX4ENSGALG00000036497Gallus gallus
 Sox4ENSMUSG00000076431Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOX11 / P35716 / SRY-box 11ENSG0000017688739
SOX12 / O15370 / SRY-box 12ENSG0000017773233
SOX10 / P56693 / SRY-box 10ENSG0000010014620
SOX7 / Q9BT81 / SRY-box 7ENSG0000017105619
SOX3 / P41225 / SRY-box 3ENSG0000013459518
SOX9 / P48436 / SRY-box 9ENSG0000012539818
SOX17 / Q9H6I2 / SRY-box 17ENSG0000016473617
SOX18 / P35713 / SRY-box 18ENSG0000020388316
SOX15 / O60248 / SRY-box 15ENSG0000012919416
SOX8 / P57073 / SRY-box 8ENSG0000000551316
SOX2 / P48431 / SRY-box 2ENSG0000018144916
SOX1 / O00570 / SRY-box 1ENSG0000018296816
SOX21 / Q9Y651 / SRY-box 21ENSG0000012528515
AC105001.2ENSG0000025872414
SOX14 / O95416 / SRY-box 14ENSG0000016887513
SRY / Q05066 / sex determining region YENSG0000018489511


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017386  Transcription factor SOX-11/4
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001841 neural tube formation IEA
 biological_processGO:0002328 pro-B cell differentiation IEA
 biological_processGO:0003183 mitral valve morphogenesis IEA
 biological_processGO:0003211 cardiac ventricle formation IEA
 biological_processGO:0003215 cardiac right ventricle morphogenesis IEA
 biological_processGO:0003289 atrial septum primum morphogenesis IEA
 biological_processGO:0003357 noradrenergic neuron differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021782 glial cell development IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035910 ascending aorta morphogenesis IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042769 DNA damage response, detection of DNA damage IDA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046826 negative regulation of protein export from nucleus IMP
 biological_processGO:0048485 sympathetic nervous system development IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060174 limb bud formation IEA
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060563 neuroepithelial cell differentiation IEA
 biological_processGO:0060993 kidney morphogenesis IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000761 positive regulation of N-terminal peptidyl-lysine acetylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0044798 nuclear transcription factor complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / reaction / complex
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction / complex






 

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