6659


Homo sapiens (NCBI)
regulationcelltranscriptionmorphogenesisdnarnapolymeraseiidevelopmentdifferentiationproteinbindingactivitysequence-specificformationdamageresponseproliferationwntsignalingpathwayfactorcardiacventricleseptumneurondna-templatedglialspinalcord

Features
Gene ID: 6659
  
Biological name :
  
Synonyms : EVI16 / SOX4 / SRY-box 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1567906_at (Human Genome U133 Plus 2.0 Array)   201416_at (Human Genome U133 Plus 2.0 Array)   201417_at (Human Genome U133 Plus 2.0 Array)   201418_s_at (Human Genome U133 Plus 2.0 Array)   213665_at (Human Genome U133 Plus 2.0 Array)   213668_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 4507163
RefSeq - NC_000006.12
RefSeq - NG_029166.1
RefSeq - NP_003098.1
RefSeq - NM_003107.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000124766 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcellular developmental processresponse to stresscell communicationcell cyclecellular response to stimuluscell activationregulation of biological qualitymacromolecule localizationestablishment of localizationmaintenance of cell numberdetection of stimuluscell deathresponse to chemicalnitrogenitrogen compound metabolic processbiosyntbiosynthetic processcellulacellular metabolic processprimaryprimary metabolic processorganicorganic substance metabolic processanatomianatomical structure developmentcellulacellular developmental processresponsresponse to stresscell cocell communicationcell cycell cyclecellulacellular response to stimuluscell accell activationregulatregulation of biological qualitymacromomacromolecule localizationestabliestablishment of localizationmaintenmaintenance of cell numberdetectidetection of stimuluscell decell deathresponsresponse to chemical
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activitytranscription coregulator activityprotein bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound bindingDNA-binding transcription faDNA-binding transcription factor activitytranscription coregulator actranscription coregulator activityprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001501 skeletal system development ISS
 biological_processGO:0001841 neural tube formation ISS
 biological_processGO:0002328 pro-B cell differentiation ISS
 biological_processGO:0003183 mitral valve morphogenesis ISS
 biological_processGO:0003211 cardiac ventricle formation ISS
 biological_processGO:0003215 cardiac right ventricle morphogenesis ISS
 biological_processGO:0003289 atrial septum primum morphogenesis ISS
 biological_processGO:0003357 noradrenergic neuron differentiation ISS
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
 biological_processGO:0007507 heart development ISS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0014009 glial cell proliferation ISS
 biological_processGO:0021510 spinal cord development ISS
 biological_processGO:0021522 spinal cord motor neuron differentiation ISS
 biological_processGO:0021782 glial cell development ISS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway ISS
 biological_processGO:0030217 T cell differentiation ISS
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032024 positive regulation of insulin secretion ISS
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035910 ascending aorta morphogenesis ISS
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0042769 DNA damage response, detection of DNA damage IDA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048485 sympathetic nervous system development ISS
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0060070 canonical Wnt signaling pathway ISS
 biological_processGO:0060174 limb bud formation ISS
 biological_processGO:0060412 ventricular septum morphogenesis ISS
 biological_processGO:0060548 negative regulation of cell death ISS
 biological_processGO:0060563 neuroepithelial cell differentiation ISS
 biological_processGO:0060993 kidney morphogenesis ISS
 biological_processGO:0071333 cellular response to glucose stimulus ISS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISS
 biological_processGO:2000761 positive regulation of N-terminal peptidyl-lysine acetylation IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0044798 nuclear transcription factor complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003713 transcription coactivator activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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