ENSG00000005513


Homo sapiens

Features
Gene ID: ENSG00000005513
  
Biological name :SOX8
  
Synonyms : P57073 / SOX8 / SRY-box 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 981808
Gene end: 986979
  
Corresponding Affymetrix probe sets: 226913_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000293894
NCBI entrez gene - 30812     See in Manteia.
OMIM - 605923
RefSeq - NM_014587
RefSeq Peptide - NP_055402
swissprot - P57073
Ensembl - ENSG00000005513
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox8aENSDARG00000105301Danio rerio
 sox8bENSDARG00000037782Danio rerio
 sox9bENSDARG00000043923Danio rerio
 SOX8ENSGALG00000005263Gallus gallus
 Sox8ENSMUSG00000024176Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOX9 / P48436 / SRY-box 9ENSG0000012539850
SOX10 / P56693 / SRY-box 10ENSG0000010014648
SOX17 / Q9H6I2 / SRY-box 17ENSG0000016473623
SOX7 / Q9BT81 / SRY-box 7ENSG0000017105622
SOX18 / P35713 / SRY-box 18ENSG0000020388321
SOX11 / P35716 / SRY-box 11ENSG0000017688719
SOX3 / P41225 / SRY-box 3ENSG0000013459517
SOX4 / Q06945 / SRY-box 4ENSG0000012476617
SOX1 / O00570 / SRY-box 1ENSG0000018296817
SOX15 / O60248 / SRY-box 15ENSG0000012919417
SOX2 / P48431 / SRY-box 2ENSG0000018144917
AC105001.2ENSG0000025872416
SOX12 / O15370 / SRY-box 12ENSG0000017773216
SOX21 / Q9Y651 / SRY-box 21ENSG0000012528515
SOX14 / O95416 / SRY-box 14ENSG0000016887514
SRY / Q05066 / sex determining region YENSG0000018489513


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022151  Sox developmental protein N-terminal
 IPR031265  Transcription factor SOX-8
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007422 peripheral nervous system development IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010817 regulation of hormone levels IEA
 biological_processGO:0014015 positive regulation of gliogenesis IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048484 enteric nervous system development IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0060009 Sertoli cell development IEA
 biological_processGO:0060018 astrocyte fate commitment IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060221 retinal rod cell differentiation IEA
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0061138 morphogenesis of a branching epithelium IEA
 biological_processGO:0072034 renal vesicle induction IEA
 biological_processGO:0072197 ureter morphogenesis IEA
 biological_processGO:0072289 metanephric nephron tubule formation IEA
 biological_processGO:0090184 positive regulation of kidney development IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0044798 nuclear transcription factor complex IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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