ENSMUSG00000024176


Mus musculus

Features
Gene ID: ENSMUSG00000024176
  
Biological name :Sox8
  
Synonyms : Q04886 / Sox8 / SRY (sex determining region Y)-box 8
  
Possible biological names infered from orthology : P57073 / SRY-box 8
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25565892
Gene end: 25570686
  
Corresponding Affymetrix probe sets: 10448967 (MoGene1.0st)   1435438_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025003
Ensembl peptide - ENSMUSP00000133403
Ensembl peptide - ENSMUSP00000133742
NCBI entrez gene - 20681     See in Manteia.
MGI - MGI:98370
RefSeq - NM_011447
RefSeq Peptide - NP_035577
swissprot - Q543C3
swissprot - G3UWS3
swissprot - G3UXL7
swissprot - Q04886
Ensembl - ENSMUSG00000024176
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox8aENSDARG00000105301Danio rerio
 sox8bENSDARG00000037782Danio rerio
 sox9bENSDARG00000043923Danio rerio
 SOX8ENSGALG00000005263Gallus gallus
 SOX8ENSG00000005513Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*ENSMUSG0000000056750
Sox10 / Q04888 / Transcription factor SOX-10 / P56693* / SRY-box 10*ENSMUSG0000003300646
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*ENSMUSG0000002590223
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*ENSMUSG0000006306022
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*ENSMUSG0000004647021
Sox11 / Q7M6Y2 / Transcription factor SOX-11 / P35716* / SRY-box 11*ENSMUSG0000006363217
Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*ENSMUSG0000007643117
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*ENSMUSG0000009601416
Sox2 / SRY-box 2 / P48431*ENSMUSG0000007463716
Sox3 / SRY-box 3 / P41225*ENSMUSG0000004517916
Sox12 / Q04890 / Transcription factor SOX-12 / O15370* / SRY-box 12*ENSMUSG0000005181715
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*ENSMUSG0000004128715
Sox21 / Q811W0 / Transcription factor SOX-21 / Q9Y651* / SRY-box 21*ENSMUSG0000006151715
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*ENSMUSG0000005374714
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*ENSMUSG0000006903612


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022151  Sox developmental protein N-terminal
 IPR031265  Transcription factor SOX-8
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007422 peripheral nervous system development IGI
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010817 regulation of hormone levels IMP
 biological_processGO:0014015 positive regulation of gliogenesis IMP
 biological_processGO:0033690 positive regulation of osteoblast proliferation IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045662 negative regulation of myoblast differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IGI
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0060009 Sertoli cell development IEP
 biological_processGO:0060018 astrocyte fate commitment IGI
 biological_processGO:0060041 retina development in camera-type eye IGI
 biological_processGO:0060221 retinal rod cell differentiation IGI
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0061138 morphogenesis of a branching epithelium IGI
 biological_processGO:0072034 renal vesicle induction IMP
 biological_processGO:0072197 ureter morphogenesis IGI
 biological_processGO:0072289 metanephric nephron tubule formation IGI
 biological_processGO:0090184 positive regulation of kidney development IGI
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0044798 nuclear transcription factor complex IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002211 abnormal primary sex determination "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1.1Mtz/Ppargtm1.1Mtz
Genetic Background: involves: C57BL/6

Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1.1Mtz/Ppargtm1.1Mtz
Genetic Background: involves: C57BL/6

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002785 absent Leydig cells "lack of the interstitial cells of the seminiferous tubules that secrete testosterone " [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
Show

Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0005652 sex reversal "development of the reproductive system is inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1.1Mtz/Ppargtm1.1Mtz
Genetic Background: involves: C57BL/6

Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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