ENSMUSG00000033006


Mus musculus

Features
Gene ID: ENSMUSG00000033006
  
Biological name :Sox10
  
Synonyms : Q04888 / Sox10 / Transcription factor SOX-10
  
Possible biological names infered from orthology : P56693 / SRY-box 10
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 79154908
Gene end: 79165240
  
Corresponding Affymetrix probe sets: 10430458 (MoGene1.0st)   1424985_a_at (Mouse Genome 430 2.0 Array)   1425369_a_at (Mouse Genome 430 2.0 Array)   1451689_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039466
Ensembl peptide - ENSMUSP00000155574
Ensembl peptide - ENSMUSP00000155639
NCBI entrez gene - 20665     See in Manteia.
MGI - MGI:98358
RefSeq - NM_011437
RefSeq Peptide - NP_035567
swissprot - Q04888
Ensembl - ENSMUSG00000033006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox10ENSDARG00000077467Danio rerio
 SOX10ENSGALG00000012290Gallus gallus
 SOX10ENSG00000100146Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*ENSMUSG0000000056758
Sox8 / Q04886 / SRY (sex determining region Y)-box 8 / P57073* / SRY-box 8*ENSMUSG0000002417646
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*ENSMUSG0000002590221
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*ENSMUSG0000004647020
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*ENSMUSG0000006306020
Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*ENSMUSG0000007643119
Sox3 / SRY-box 3 / P41225*ENSMUSG0000004517918
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*ENSMUSG0000009601417
Sox12 / Q04890 / Transcription factor SOX-12 / O15370* / SRY-box 12*ENSMUSG0000005181717
Sox11 / Q7M6Y2 / Transcription factor SOX-11 / P35716* / SRY-box 11*ENSMUSG0000006363217
Sox2 / SRY-box 2 / P48431*ENSMUSG0000007463717
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*ENSMUSG0000004128715
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*ENSMUSG0000005374714
Sox21 / Q811W0 / Transcription factor SOX-21 / Q9Y651* / SRY-box 21*ENSMUSG0000006151714
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*ENSMUSG0000006903613


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022151  Sox developmental protein N-terminal
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0002052 positive regulation of neuroblast proliferation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IDA
 biological_processGO:0007422 peripheral nervous system development IGI
 biological_processGO:0010626 negative regulation of Schwann cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0014015 positive regulation of gliogenesis IMP
 biological_processGO:0022010 central nervous system myelination IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0031643 positive regulation of myelination IMP
 biological_processGO:0032808 lacrimal gland development IMP
 biological_processGO:0035690 cellular response to drug IEP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048863 stem cell differentiation IEP
 biological_processGO:0061138 morphogenesis of a branching epithelium IMP
 biological_processGO:0071393 cellular response to progesterone stimulus IEP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031315 extrinsic component of mitochondrial outer membrane IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IGI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:1990841 promoter-specific chromatin binding IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000370 head blaze "the appearance of a stripe of white fur on the head" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: involves: C57BL/6 * GT/Le

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

Allelic Composition: Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sox10df10R/Sox10+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sox10df8R/Sox10+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Gli3Xt-J/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Allelic Composition: Gli3Mos1/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

Allelic Composition: Sox10M2Btlr/?
Genetic Background: C57BL/6J-Sox10M2Btlr

Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

Allelic Composition: Sox10tm8.1Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0000394 absent melanin granules in hair follicle "missing pigment polymers in the hair follicles" [J:18378]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gutl1C3HeB/FeJ/Gutl1C3HeB/FeJ,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10m2C3HeB/FeJ/Sox10m2C3HeB/FeJ,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10Dom/Sox10+,Tg(DBHn-lacZ)8Rpk/0
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe * SJL

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox10Dom/Sox10+,Tg(DBHn-lacZ)8Rpk/0
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe * SJL

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10Dom/Sox10+,Tg(DBHn-lacZ)8Rpk/0
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe * SJL

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: involves: C57BL/6 * GT/Le

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Traf4m1Pav/Traf4m1Pav,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: EdaTa-26H/Eda+
Genetic Background: Not Specified

Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Sox10tm6(Sox100B)Weg/Sox10tm6(Sox100B)Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0001025 abnormal sympathetic neuron morphology "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox10tm6(Sox100B)Weg/Sox10tm6(Sox100B)Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0001034 abnormal parasympathetic ganglia morphology "malformation or absence of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox10Dom/Sox10+,Tg(DBHn-lacZ)8Rpk/0
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe * SJL

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C57BL/6J-Sox10Dom

Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C3Fe.B6JLe-Sox10Dom

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C57BL/6J-Sox10Dom

Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C3Fe.B6JLe-Sox10Dom

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Sox10tm5Weg/Sox10tm5Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm4Weg/Sox10tm4Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10Dom/Sox10+
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0001087 abnormal nodose ganglion morphology "malformation of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0001105 abnormal PNS glia "malformation or absence of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox10tm5Weg/Sox10tm5Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm4Weg/Sox10tm4Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J

 MP:0001108 absent Schwann cells "missing cells that sheath the axons of the peripheral nervous system" [J:43515]
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Allelic Composition: Sox10tm8.1Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0001189 absent skin pigmentation "lack of pigmentation of the skin" [J:53370]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MitfMi/MitfMi
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: involves: C57BL/6 * GT/Le

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EdaTa-26H/Eda+
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10tm5Weg/Sox10tm5Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm1.1Sout/Sox10tm1.1Sout
Genetic Background: involves: C57BL/6N

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

Allelic Composition: Sox10gt/Sox10+
Genetic Background: HYIII/LeJ

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

 MP:0002671 belted "the appearance of a stripe of white fur around the circumference of the abdomen" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli3Xt-J/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Allelic Composition: Gli3Mos1/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Efnb3tm1.2Henk/Efnb3tm1.2Henk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

Allelic Composition: Sox10gt/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * GT/Le

Allelic Composition: Sox10tm8.1Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0002738 hyperresponsive to tactile stimuli "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0002926 aganglionic megacolon "extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2(HIF1A/luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sox10m2C3HeB/FeJ/Sox10m2C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10m3C57BL/6J/Sox10m3C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10m3C3HeB/FeJ/Sox10m3C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10m4C57BL/6J/Sox10m4C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10m4C3HeB/FeJ/Sox10m4C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10m5C57BL/6J/Sox10m5C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10m5C3HeB/FeJ/Sox10m5C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10tm4Weg/Sox10tm4Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C57BL/6J-Sox10Dom

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10Dom/Sox10+,Tg(DBHn-lacZ)8Rpk/0
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe * SJL

 MP:0002940 variable body spotting "the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb3tm1.2Henk/Efnb3tm1.2Henk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Sox10Dal/Sox10+
Genetic Background: C57BL/6J-Sox10Dal

Allelic Composition: Sox10M2J/Sox10+
Genetic Background: B6Ei.Cg-Sox10M2J/GrsrJ

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

Allelic Composition: Sox10Dom/Sox10+
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0005171 lack of coat pigmentation "fur is devoid of coloration and appears white " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Sox10gt/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * GT/Le

 MP:0005175 non-pigmented tail tip "lack of color at the end of the tail " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd2tm1Som/Pkd2tm2Som
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Gli3Xt-J/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Allelic Composition: Gli3Mos1/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Erbb3msp1/Erbb3msp1,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Traf4m1Pav/Traf4m1Pav,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Smarcc1msp3/Smarcc1msp3,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: msp4/msp4,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Mos3/Mos3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0006408 dorsal root ganglion hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, of a dorsal root ganglion or ganglia" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10tm5Weg/Sox10tm5Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm4Weg/Sox10tm4Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm6(Sox100B)Weg/Sox10tm6(Sox100B)Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

Allelic Composition: Sox10gt/Sox10+
Genetic Background: GT/Le

Allelic Composition: Sox10gt/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * GT/Le

 MP:0008289 abnormal adrenal medulla morphology "any structural anomaly of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine" [MESH:A06.407.071.265, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10tm6(Sox100B)Weg/Sox10tm6(Sox100B)Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0008492 dorsal root ganglion degeneration "retrogressive pathological change of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008917 abnormal oligodendrocyte physiology "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J

Allelic Composition: Sox10tm8.1Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H

Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Sox10tm6(Sox100B)Weg/Sox10tm6(Sox100B)Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009783 abnormal melanoblast morphology "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Sox10tm6(Sox100B)Weg/Sox10tm6(Sox100B)Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0009784 abnormal melanoblast migration "defect in the dispersion of the cells that originate from the neural crest and differentiate into pigment cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10tm5Weg/Sox10tm5Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm4Weg/Sox10tm4Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Sox10tm5Weg/Sox10tm5Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0009843 decreased neural crest cell number "reduction in the number of ransient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe

 MP:0009846 abnormal neural crest morphology 
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Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10tm7.1(Sox10)Weg/Sox10tm7.1(Sox10)Weg,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Efnb3tm1.2Henk/Efnb3tm1.2Henk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

Allelic Composition: Sox10tm4Weg/Sox10tm4Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sox10gt/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * GT/Le

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Sox10tm6(Sox100B)Weg/Sox10tm6(Sox100B)Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm8.1Weg/Sox10tm8.1Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Sox10tm5Weg/Sox10tm5Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Sox10tm4Weg/Sox10tm4Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mc4rGlu3/Mc4r+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Erbb3msp1/Erbb3msp1,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Smarcc1msp3/Smarcc1msp3,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Erbb3msp1/Erbb3msp1,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Erbb3msp1/Erbb3msp1,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Traf4m1Pav/Traf4m1Pav,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: msp4/msp4,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0011266 abnormal frontonasal mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011277 decreased tail pigmentation "visually detectable dilution of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Sox10M2J/Sox10+
Genetic Background: B6Ei.Cg-Sox10M2J/GrsrJ

 MP:0011568 decreased foot pigmentation "visually detectable dilution of pigment present on the foot surface" [MGI:csmith]
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Allelic Composition: Sox10M2J/Sox10+
Genetic Background: B6Ei.Cg-Sox10M2J/GrsrJ

Allelic Composition: Sox10M2Btlr/?
Genetic Background: C57BL/6J-Sox10M2Btlr

Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

 MP:0011805 decreased cell migration "reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011904 abnormal Schwann cell physiology "any functional anomaly of the cells which form the insulating myelin sheaths of peripheral axons" [MESH:A08.637.800]
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Allelic Composition: Sox10tm8.1Weg/Sox10tm8.1Weg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0012023 decreased melanocyte number "reduced number of the cells that produce pigment" [MGI:llw2]
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Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10tm1Weg/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Allelic Composition: Sox10gt/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * GT/Le

 MP:0012745 abnormal neural crest cell physiology "any functional anomaly in the complex process by which multipotent neural crest progenitors acquire migratory and invasive properties, emigrate from the dorsal aspect of the neural tube, migrate along distinct pathways, and differentiate into diverse cell types" [MGI:anna]
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Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C57BL/6J-Sox10Dom

Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C3Fe.B6JLe-Sox10Dom

 MP:0013001 abnormal enteric neural crest cell morphology " any structural anomaly of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; neural crest cells are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans)" [MGI:anna, PMID:17514199]
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Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C57BL/6J-Sox10Dom

Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C3Fe.B6JLe-Sox10Dom

 MP:0013006 abnormal enteric neural crest cell migration "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; NCCs are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) and the colonization process is complete by E15.5 (after 7 weeks gestation in humans)" [MGI:anna, PMID:17514199]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

 MP:0013007 abnormal vagal neural crest cell migration "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7; at approximately E8.5-9 in the mouse, vagal NCCs invade the anterior foregut and migrate in a rostral to caudal direction to colonize the entire foregut, midgut, cecum, and hindgut and give rise to the majority of the enteric nervous system (ENS); colonization is complete by E15.5 (or after 7 weeks gestation in humans); the most caudal vagal NCCs, emanating from a region overlapping with the most anterior trunk NCCs, make a small contribution to the ENS of the esophagus and the anterior stomach" [MGI:anna, PMID:17514199]
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Allelic Composition: Sox10Dom/Sox10+,Tg(DBHn-lacZ)8Rpk/0
Genetic Background: involves: C3HeB/FeJLe * C57BL/6JLe * SJL

 MP:0013009 increased vagal neural crest cell apoptosis "increased number of vagal neural crest cells (NCCs) undergoing programmed cell death" [MGI:anna, PMID:22016183]
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Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: B6.129S2-Ifnar1tm1Agt

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
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Allelic Composition: Sox10gt/Sox10gt
Genetic Background: GT/Le

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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