ENSMUSG00000045179


Mus musculus

Features
Gene ID: ENSMUSG00000045179
  
Biological name :Sox3
  
Synonyms : Sox3 / SRY-box 3
  
Possible biological names infered from orthology : P41225
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A6
Gene start: 60891366
Gene end: 60893430
  
Corresponding Affymetrix probe sets: 10604837 (MoGene1.0st)   1435192_at (Mouse Genome 430 2.0 Array)   1450485_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115237
NCBI entrez gene - 20675     See in Manteia.
MGI - MGI:98365
RefSeq - NM_009237
RefSeq Peptide - NP_033263
swissprot - A2AM37
Ensembl - ENSMUSG00000045179
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox3ENSDARG00000053569Danio rerio
 SOX3ENSG00000134595Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*ENSMUSG0000009601449
Sox2 / SRY-box 2 / P48431*ENSMUSG0000007463743
Sox21 / Q811W0 / Transcription factor SOX-21 / Q9Y651* / SRY-box 21*ENSMUSG0000006151724
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*ENSMUSG0000005374723
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*ENSMUSG0000004128722
Sox10 / Q04888 / Transcription factor SOX-10 / P56693* / SRY-box 10*ENSMUSG0000003300619
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*ENSMUSG0000004647019
Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*ENSMUSG0000000056718
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*ENSMUSG0000006306018
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*ENSMUSG0000002590218
Sox11 / Q7M6Y2 / Transcription factor SOX-11 / P35716* / SRY-box 11*ENSMUSG0000006363217
Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*ENSMUSG0000007643117
Sox8 / Q04886 / SRY (sex determining region Y)-box 8 / P57073* / SRY-box 8*ENSMUSG0000002417616
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*ENSMUSG0000006903615
Sox12 / Q04890 / Transcription factor SOX-12 / O15370* / SRY-box 12*ENSMUSG0000005181714


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022097  Transcription factor SOX
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007530 sex determination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0008221 abnormal hippocampal commissure morphology "any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0009463 abnormal pituitary infundibular stalk "any structural anomaly of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0013337 abnormal adenohypophysis development "aberrant formation or incomplete differentiation of the anterior lobe of the pituitary gland which arises as a pouch-like outgrowth of ectoderm known as the hypophyseal (Rathke s) pouch from the dorsal midline roof of the stomodeum (primitive oral cavity); the hypophyseal pouch grows toward the brain and the neurohypophyseal bud; as the hypophyseal pouch and the infundibulum make contact, the hypophyseal pouch loses its connection with the pharynx, creating a hollow ball of cells that lies inferior to the floor of the diencephalon posterior to the optic chiasm; these cells undergo division, the central chamber gradually disappears, and this endocrine mass becomes the anterior pituitary gland; the fully developed adenohypophysis consists of a glandular pars distalis, a thin proximal extension called the pars tuberalis, and a narrow pars intermedia" [MGI:Anna]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

 MP:0013342 bifurcated Rathke s pouch "the appearance of an abnormal division in the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed " [MGI:Anna, PMID:19074474]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0013351 abnormal Rathke s pouch development "any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim,Stiltm1Mku/Stiltm1Mku
Genetic Background: involves: 129/Sv

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0014198 absent pituitary infundibular stalk "absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland" [MGI:Anna]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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