ENSMUSG00000074637


Mus musculus

Features
Gene ID: ENSMUSG00000074637
  
Biological name :Sox2
  
Synonyms : Sox2 / SRY-box 2
  
Possible biological names infered from orthology : P48431
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 34650405
Gene end: 34652461
  
Corresponding Affymetrix probe sets: 10491477 (MoGene1.0st)   1416967_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096755
NCBI entrez gene - 20674     See in Manteia.
MGI - MGI:98364
RefSeq - NM_011443
RefSeq Peptide - NP_035573
swissprot - Q60I23
Ensembl - ENSMUSG00000074637
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox2ENSDARG00000070913Danio rerio
 SOX2ENSGALG00000043460Gallus gallus
 SOX2ENSG00000181449Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*ENSMUSG0000009601461
Sox3 / SRY-box 3 / P41225*ENSMUSG0000004517960
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*ENSMUSG0000005374733
Sox21 / Q811W0 / Transcription factor SOX-21 / Q9Y651* / SRY-box 21*ENSMUSG0000006151732
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*ENSMUSG0000004128729
Sox10 / Q04888 / Transcription factor SOX-10 / P56693* / SRY-box 10*ENSMUSG0000003300625
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*ENSMUSG0000002590225
Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*ENSMUSG0000000056725
Sox8 / Q04886 / SRY (sex determining region Y)-box 8 / P57073* / SRY-box 8*ENSMUSG0000002417624
Sox11 / Q7M6Y2 / Transcription factor SOX-11 / P35716* / SRY-box 11*ENSMUSG0000006363224
Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*ENSMUSG0000007643123
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*ENSMUSG0000006306023
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*ENSMUSG0000004647023
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*ENSMUSG0000006903620
Sox12 / Q04890 / Transcription factor SOX-12 / O15370* / SRY-box 12*ENSMUSG0000005181719


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022097  Transcription factor SOX
 IPR032643  Transcription factor SOX-2
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001714 endodermal cell fate specification IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0021984 adenohypophysis development IEA
 biological_processGO:0022409 positive regulation of cell-cell adhesion IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000046 abnormal sulcus ampullaris morphology "anomaly in the structure of the transverse groove on the membranous amupulla of each semicircular duct, where the nerve enters the ampullary crest" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2tm1Rlb/Sox2ysb
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Sox2lcc/Sox2tm1Rlb
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000397 abnormal guard hair "anomalies of truncal hairs that contain two air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2lcc/Sox2+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2lcc/Sox2+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000405 abnormal auchene hairs "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0000467 abnormal esophagus morphology "malformation of the part of the digestive canal through which food passes from the pharynx to the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm1Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000469 abnormal esophageal squamous epithelium morphology "malformation of the scaly epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Sox2tm1Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm1Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Sox2tm1Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0000948 nonconvulsive seizures "seizures without uncontrolled motor activity, but with impairment of consciousness" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001288 abnormal lens induction "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm1Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm1Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox1tm1Vep/Sox1tm2Vep,Sox2tm1Vep/Sox2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Sox2tm1.1Lan/Sox2tm1.1Lan,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Pax6Sey-Neu/Pax6+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 102 * C3H * C3H/HeN

Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3tm1.1Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm1Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

 MP:0001329 retina hyperplasia "greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm1Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2lcc/Sox2ysb
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2tm1Rlb/Sox2ysb
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Sox2lcc/Sox2ysb
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2lcc/Sox2+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0001526 abnormal placing response "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Sox2tm1.2Vlcg/Sox2tm1.2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Sox2tm1.1Vep/Sox2tm1.2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001717 absent ectoplacental cone 
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Sox2lcc/Sox2tm1Rlb
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Sox2tm1Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2tm1Rlb/Sox2ysb
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox1tm1Vep/Sox1tm2Vep,Sox2tm1Vep/Sox2+
Genetic Background: involves: 129S/SvEv

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2ysb/Sox2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm1Rlb/Sox2ysb
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Sox1tm1Vep/Sox1tm2Vep,Sox2tm1Vep/Sox2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx6tm1Pa/Tbx6tm1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hnf4atm2Mwei/Hnf4atm2Mwei
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sox2tm2Lpev/Sox2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm3Lpev/Sox2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm3Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm4Lpev/Sox2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm1.1Vep/Sox2+
Genetic Background: Not Specified

Allelic Composition: Sox2tm1Vep/Sox2+
Genetic Background: Not Specified

Allelic Composition: Sox2tm1.2Vlcg/Sox2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Sox2tm1.1Vlcg/Sox2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2tm1Rlb/Sox2ysb
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Sox2lcc/Sox2tm1Rlb
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0002653 abnormal ependyma morphology "malformation or absence of the cellular membrane that lines the brain ventricles and the central canal of the spinal cord" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox2tm1Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
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Allelic Composition: Pax3tm1.1Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2ysb/Sox2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sox2lcc/Sox2ysb
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2tm1Rlb/Sox2ysb
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Sox2tm1.1Lan/Sox2tm1.1Lan,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0003276 esophageal atresia "congenital blockage or absence of the lumen of the esophagus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox2tm1Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003300 gastrointestinal ulcer "any lesion on the mucosal surface of the gastrointestinal tract, usually produced by the sloughing of inflammatory necrotic tissue" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sox2tm1Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd274tm1Shr/Cd274tm1Shr,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

 MP:0003817 abnormal Rathke s pouch "malformation or incomplete differentiation of a pouch of ectoderm that grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Sox2tm1.1(cre/ERT2)Jpmb/Sox2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0004317 small saccule "reduced size of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2lcc/Sox2tm1Rlb
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0004325 absent vestibular hair cells "absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0004336 small utricle "reduced size of the larger of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Sox2lcc/Sox2tm1Rlb
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

 MP:0004416 absent cochlear nerve compound action potential "absence of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2lcc/Sox2ysb
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA

Allelic Composition: Sox2lcc/Sox2lcc
Genetic Background: involves: 101/H * C3H/HeH

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0004493 dilated cochlea "the luminal space of the cochlea is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nuak2tm1Esu/Nuak2+
Genetic Background: B6.129S4-Nuak2tm1Esu

Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0005128 decreased adrenocorticotropin level "decreased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005132 decreased luteinizing hormone level "lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005138 decreased prolactin level "less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005267 abnormal olfactory cortex morphology "anomalous structure of piriform cortex, part of the olfactory tract, which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83884]
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Allelic Composition: Sox1tm1Vep/Sox1tm2Vep,Sox2tm1Vep/Sox2+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox1tm1Vep/Sox1tm1Vep,Sox2tm1Vep/Sox2+
Genetic Background: involves: 129S/SvEv

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Twist1Ska10/Twist1Ska10
Genetic Background: C57BL/6J-Twist1Ska10

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0006071 abnormal retinal progenitor morphology "anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Sox2tm1Rlb/Sox2ysb
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0006221 optic nerve hypoplasia "less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm1Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

 MP:0006257 abnormal fungiform papillae "malformation, absence, or atypical size or shape of the mushroom-shaped papillae, which have a single tase bud at the tip, located mostly on the dorsal anterior portion of the tongue " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

 MP:0006293 absent olfactory placodes "absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes " [J:71787, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1tm1Shrp,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1.1Myok/Atg5tm1.1Myok,Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/Col1a1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008329 decreased somatotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Sox2tm1Okud/Sox2tm1Okud,Tg(Nes-cre)1Sasa/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0008794 increased lens epithelium apopotosis "increase in the number of lens epithelial cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Sox2tm1.1Lan/Sox2tm1.1Lan,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm1.2Vlcg/Sox2tm1.2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Sox2tm1.1Vep/Sox2tm1.2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0009533 absent palatine gland "absence of the salivary gland of the hard palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009534 absent anterior lingual gland "absence of the small glands located near the apex of the tongue on either side of the frenulum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Sox2tm1.1(cre/ERT2)Jpmb/Sox2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0010371 abnormal epiglottis morphology "any structural anomaly of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010863 absent respiratory mucosa goblet cells "absence of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010897 abnormal bronchiole epithelium morphology "any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011054 absent respiratory motile cilia "absence of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011071 absent Clara cells "absence of the rounded, club-shaped, nonciliated cells found between ciliated cells in the bronchiolar epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Sox2tm4Lpev/Sox2tm4Lpev
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sox2tm1Okud/Sox2tm1Okud,Tg(Nes-cre)1Sasa/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox2tm1Lpev/Sox2tm2Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Sox2tm1.2Vlcg/Sox2tm1.2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Sox2tm1.1Vep/Sox2tm1.2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Cdk12tm1.1Mjfn/Cdk12tm1.2Mjfn,Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
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Allelic Composition: Sox2tm1.2Vlcg/Sox2tm1.2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Sox2tm1.1Vep/Sox2tm1.2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0013337 abnormal adenohypophysis development "aberrant formation or incomplete differentiation of the anterior lobe of the pituitary gland which arises as a pouch-like outgrowth of ectoderm known as the hypophyseal (Rathke s) pouch from the dorsal midline roof of the stomodeum (primitive oral cavity); the hypophyseal pouch grows toward the brain and the neurohypophyseal bud; as the hypophyseal pouch and the infundibulum make contact, the hypophyseal pouch loses its connection with the pharynx, creating a hollow ball of cells that lies inferior to the floor of the diencephalon posterior to the optic chiasm; these cells undergo division, the central chamber gradually disappears, and this endocrine mass becomes the anterior pituitary gland; the fully developed adenohypophysis consists of a glandular pars distalis, a thin proximal extension called the pars tuberalis, and a narrow pars intermedia" [MGI:Anna]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0013342 bifurcated Rathke s pouch "the appearance of an abnormal division in the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed " [MGI:Anna, PMID:19074474]
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Allelic Composition: Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0030129 tongue inflammation "local accumulation of fluid, plasma proteins and leukocytes in the tongue" [MGI:anna]
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Allelic Composition: Sox2tm3(TK)Hoch/Sox2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:3000003 abnormal Ebner s gland morphology "any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete lingual lipase initiating the process of lipid hydrolysis in the mouth and empty their serous secretion into the base of the moats around the foliate and circumvallate papillae; their secretion presumably flushes material from the moat to enable the taste buds to respond rapidly to changing stimuli." [GOC:TermGenie, MGI:Anna]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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