ENSMUSG00000061517


Mus musculus

Features
Gene ID: ENSMUSG00000061517
  
Biological name :Sox21
  
Synonyms : Q811W0 / Sox21 / Transcription factor SOX-21
  
Possible biological names infered from orthology : Q9Y651 / SRY-box 21
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E4
Gene start: 118233232
Gene end: 118237030
  
Corresponding Affymetrix probe sets: 10422272 (MoGene1.0st)   1437059_at (Mouse Genome 430 2.0 Array)   1451835_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127396
NCBI entrez gene - 223227     See in Manteia.
MGI - MGI:2654070
RefSeq - NM_177753
RefSeq Peptide - NP_808421
swissprot - Q811W0
Ensembl - ENSMUSG00000061517
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6RVD7ENSDARG00000008540Danio rerio
 SOX21ENSGALG00000035157Gallus gallus
 SOX21ENSG00000125285Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*ENSMUSG0000005374758
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*ENSMUSG0000009601441
Sox3 / SRY-box 3 / P41225*ENSMUSG0000004517939
Sox2 / SRY-box 2 / P48431*ENSMUSG0000007463737
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*ENSMUSG0000004128729
Sox11 / Q7M6Y2 / Transcription factor SOX-11 / P35716* / SRY-box 11*ENSMUSG0000006363226
Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*ENSMUSG0000000056725
Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*ENSMUSG0000007643125
Sox8 / Q04886 / SRY (sex determining region Y)-box 8 / P57073* / SRY-box 8*ENSMUSG0000002417625
Sox10 / Q04888 / Transcription factor SOX-10 / P56693* / SRY-box 10*ENSMUSG0000003300624
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*ENSMUSG0000002590224
Sox12 / Q04890 / Transcription factor SOX-12 / O15370* / SRY-box 12*ENSMUSG0000005181723
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*ENSMUSG0000006903622
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*ENSMUSG0000006306021
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*ENSMUSG0000004647020


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022097  Transcription factor SOX
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0042633 hair cycle IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048863 stem cell differentiation IEA
 cellular_componentGO:0005634 nucleus IC
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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