ENSMUSG00000051817


Mus musculus

Features
Gene ID: ENSMUSG00000051817
  
Biological name :Sox12
  
Synonyms : Q04890 / Sox12 / Transcription factor SOX-12
  
Possible biological names infered from orthology : O15370 / SRY-box 12
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 152393611
Gene end: 152398063
  
Corresponding Affymetrix probe sets: 10488623 (MoGene1.0st)   1439754_at (Mouse Genome 430 2.0 Array)   1455562_at (Mouse Genome 430 2.0 Array)   1456882_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064250
Ensembl peptide - ENSMUSP00000138293
NCBI entrez gene - 20667     See in Manteia.
MGI - MGI:98360
RefSeq - NM_011438
RefSeq Peptide - NP_035568
swissprot - Q04890
Ensembl - ENSMUSG00000051817
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox12ENSDARG00000025847Danio rerio
 SOX12ENSGALG00000035951Gallus gallus
 SOX12ENSG00000177732Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*ENSMUSG0000007643150
Sox11 / Q7M6Y2 / Transcription factor SOX-11 / P35716* / SRY-box 11*ENSMUSG0000006363241
Sox10 / Q04888 / Transcription factor SOX-10 / P56693* / SRY-box 10*ENSMUSG0000003300625
Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*ENSMUSG0000000056724
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*ENSMUSG0000006306023
Sox8 / Q04886 / SRY (sex determining region Y)-box 8 / P57073* / SRY-box 8*ENSMUSG0000002417623
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*ENSMUSG0000004647021
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*ENSMUSG0000004128720
Sox3 / SRY-box 3 / P41225*ENSMUSG0000004517920
Sox21 / Q811W0 / Transcription factor SOX-21 / Q9Y651* / SRY-box 21*ENSMUSG0000006151720
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*ENSMUSG0000002590220
Sox2 / SRY-box 2 / P48431*ENSMUSG0000007463720
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*ENSMUSG0000009601419
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*ENSMUSG0000005374718
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*ENSMUSG0000006903617


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017386  Transcription factor SOX-11/4
 IPR031267  Transcription factor SOX-12
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0021510 spinal cord development IDA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0065004 protein-DNA complex assembly IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0032993 protein-DNA complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Sox12tm2.1Weg/Sox12tm2.1Weg
Genetic Background: involves: 129 * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011261 abnormal limb mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Sox11tm2.1Weg/Sox11tm2.1Weg,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1Vlf/Sox4tm1Vlf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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