Manteia

ENSDARG00000070913

Danio rerio

Features

Gene ID:	ENSDARG00000070913

Biological name :	sox2

Synonyms :	Q6P0E1 / sox2 / SRY (sex determining region Y)-box 2

Possible biological names infered from orthology :	P48431 / SRY-box 2

Species:	Danio rerio

Chr. number:	22
Strand:	-1
Band:
Gene start:	37347896
Gene end:	37349967

Corresponding Affymetrix probe sets:	Dr.5379.1.A1_at (Zebrafish Array) DrAffx.2.82.A1_at (Zebrafish Array) DrAffx.2.82.S1_at (Zebrafish Array) NM_213118_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000095266 NCBI entrez gene - 378723 See in Manteia. RefSeq - NM_213118 RefSeq Peptide - NP_998283 swissprot - Q6P0E1 ZFIN ID - ZDB-GENE-030909-1 Ensembl - ENSDARG00000070913

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
SOX2	ENSGALG00000043460	Gallus gallus
SOX2	ENSG00000181449	Homo sapiens
Sox2	ENSMUSG00000074637	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
sox3 / Q6EJB7 / SRY (sex determining region Y)-box 3 / P41225* / SRY-box 3*	ENSDARG00000053569	63
sox1b / Q2Z1R2 / SRY (sex determining region Y)-box 1b / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *	ENSDARG00000008131	61
sox1a / Q6DGL6 / SRY (sex determining region Y)-box 1a / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *	ENSDARG00000069866	58
sox19b / SRY (sex determining region Y)-box 19b	ENSDARG00000040266	51
P47792 / sox19a / SRY (sex determining region Y)-box 19a	ENSDARG00000010770	50
sox14 / Q32PP9 / SRY (sex determining region Y)-box 14 / Q04892* / O95416* / SRY-box 14* / Transcription factor SOX-14 *	ENSDARG00000070929	34
FQ377628.2	ENSDARG00000111969	32
Q6RVD7 / sox21b / SRY (sex determining region Y)-box 21b / SOX21* / Q9Y651* / Q811W0* / SRY-box 21* / Transcription factor SOX-21 *	ENSDARG00000008540	31
sox21a / SRY (sex determining region Y)-box 21a	ENSDARG00000031664	31
sox9a / SRY (sex determining region Y)-box 9a / SOX9* / Q04887* / P48436* / SRY-box 9* / Transcription factor SOX-9 *	ENSDARG00000003293	24
sox9b / SRY (sex determining region Y)-box 9b / SOX8* / P57073* / SRY-box 8*	ENSDARG00000043923	24
sox10 / SRY (sex determining region Y)-box 10 / Q04888* / P56693* / SRY-box 10* / Transcription factor SOX-10 *	ENSDARG00000077467	24
sox11b / SRY (sex determining region Y)-box 11b / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *	ENSDARG00000095743	23
sox12 / SRY (sex determining region Y)-box 12 / Q04890* / O15370* / SRY-box 12* / Transcription factor SOX-12 *	ENSDARG00000025847	23
sox8b / SRY (sex determining region Y)-box 8b / SOX8* / P57073* / SRY-box 8*	ENSDARG00000037782	22
sox18 / SRY (sex determining region Y)-box 18 / P43680* / P35713* / SRY-box 18* / Transcription factor SOX-18 *	ENSDARG00000058598	22
sox11a / SRY (sex determining region Y)-box 11a / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *	ENSDARG00000077811	22
sox4b / SRY (sex determining region Y)-box 4b / SOX4* / Q06945* / SRY-box 4*	ENSDARG00000098834	22
sox7 / SRY (sex determining region Y)-box 7 / Q9BT81* / P40646* / SRY-box 7* / AC105001.2*	ENSDARG00000030125	21
sox4a / SRY (sex determining region Y)-box 4a / SOX4* / Q06945* / Q06831* / SRY-box 4* / Transcription factor SOX-4 *	ENSDARG00000004588	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR009071	High mobility group box domain
IPR022097	Transcription factor SOX
IPR032643	Transcription factor SOX-2

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008283	cell proliferation	IMP
biological_process	GO:0021538	epithalamus development	IMP
biological_process	GO:0021982	pineal gland development	IMP
biological_process	GO:0031099	regeneration	IMP
biological_process	GO:0031101	fin regeneration	IMP
biological_process	GO:0048592	eye morphogenesis	IMP
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA
biological_process	GO:0060119	inner ear receptor cell development	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005667	transcription factor complex	IC
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IDA
molecular_function	GO:0043565	sequence-specific DNA binding	IPI

Pathways (from Reactome)

Pathway description

Deactivation of the beta-catenin transactivating complex

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000030	macula utricle	macula utricle cell death increased occurrence , abnormal	Show
ZFA:0000037	anatomical structure	anatomical structure increased amount , abnormal	Show
ZFA:0000050	optic vesicle	optic vesicle has extra parts of type hair cell , abnormal	Show
ZFA:0000107	eye	eye decreased size , abnormal	Show
ZFA:0000155	somite	somite shape , abnormal	Show
ZFA:0001058	caudal fin	caudal fin upturned , abnormal	Show
ZFA:0001094	whole organism	whole organism decreased length , abnormal	Show
ZFA:0001359	pineal complex	pineal complex photoreceptor cell increased amount , abnormal	Show
ZFA:0001360	parapineal organ	parapineal organ epithalamus development process quality , abnormal parapineal organ determination of left/right asymmetry in diencephalon process quality , abnormal	Show
ZFA:0007000	macula saccule	macula saccule cell death increased occurrence , abnormal	Show
ZFA:0009033	ependymal cell	ependymal cell cell proliferation decreased process quality , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr