ENSDARG00000077467


Danio rerio

Features
Gene ID: ENSDARG00000077467
  
Biological name :sox10
  
Synonyms : sox10 / SRY (sex determining region Y)-box 10
  
Possible biological names infered from orthology : P56693 / Q04888 / SRY-box 10 / Transcription factor SOX-10
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 1492174
Gene end: 1501255
  
Corresponding Affymetrix probe sets: Dr.12604.1.S1_at (Zebrafish Array)   NM_131875_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000100237
NCBI entrez gene - 140616     See in Manteia.
RefSeq - NM_131875
RefSeq Peptide - NP_571950
swissprot - Q90XD1
ZFIN ID - ZDB-GENE-011207-1
Ensembl - ENSDARG00000077467
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOX10ENSGALG00000012290Gallus gallus
 SOX10ENSG00000100146Homo sapiens
 Sox10ENSMUSG00000033006Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sox9a / SRY (sex determining region Y)-box 9a / SOX9* / Q04887* / P48436* / SRY-box 9* / Transcription factor SOX-9 *ENSDARG0000000329349
sox9b / SRY (sex determining region Y)-box 9b / SOX8* / P57073* / SRY-box 8*ENSDARG0000004392344
sox8b / SRY (sex determining region Y)-box 8b / SOX8* / P57073* / SRY-box 8*ENSDARG0000003778238
sox8a / SRY (sex determining region Y)-box 8a / SOX8* / P57073* / SRY-box 8*ENSDARG0000010530138
sox18 / SRY (sex determining region Y)-box 18 / P43680* / P35713* / SRY-box 18* / Transcription factor SOX-18 *ENSDARG0000005859818
sox17 / SRY (sex determining region Y)-box 17 / Q9H6I2* / SRY-box 17*ENSDARG0000010171717
sox7 / SRY (sex determining region Y)-box 7 / Q9BT81* / P40646* / SRY-box 7* / AC105001.2*ENSDARG0000003012517
sox1a / Q6DGL6 / SRY (sex determining region Y)-box 1a / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *ENSDARG0000006986616
sox4b / SRY (sex determining region Y)-box 4b / SOX4* / Q06945* / SRY-box 4*ENSDARG0000009883416
sox4a / SRY (sex determining region Y)-box 4a / SOX4* / Q06945* / Q06831* / SRY-box 4* / Transcription factor SOX-4 *ENSDARG0000000458816
sox1b / Q2Z1R2 / SRY (sex determining region Y)-box 1b / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *ENSDARG0000000813116
sox2 / Q6P0E1 / SRY (sex determining region Y)-box 2 / P48431* / SRY-box 2*ENSDARG0000007091315
sox12 / SRY (sex determining region Y)-box 12 / Q04890* / O15370* / SRY-box 12* / Transcription factor SOX-12 *ENSDARG0000002584715
sox11b / SRY (sex determining region Y)-box 11b / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *ENSDARG0000009574315
sox19b / SRY (sex determining region Y)-box 19bENSDARG0000004026614
sox11a / SRY (sex determining region Y)-box 11a / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *ENSDARG0000007781114
P47792 / sox19a / SRY (sex determining region Y)-box 19aENSDARG0000001077014
sox3 / Q6EJB7 / SRY (sex determining region Y)-box 3 / P41225* / SRY-box 3*ENSDARG0000005356914
sox14 / Q32PP9 / SRY (sex determining region Y)-box 14 / Q04892* / O95416* / SRY-box 14* / Transcription factor SOX-14 *ENSDARG0000007092913
Q6RVD7 / sox21b / SRY (sex determining region Y)-box 21b / SOX21* / Q9Y651* / Q811W0* / SRY-box 21* / Transcription factor SOX-21 *ENSDARG0000000854013


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022151  Sox developmental protein N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0010001 glial cell differentiation IGI
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0014037 Schwann cell differentiation IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0022011 myelination in peripheral nervous system IGI
 biological_processGO:0030318 melanocyte differentiation IGI
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048752 semicircular canal morphogenesis IMP
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0050768 negative regulation of neurogenesis IMP
 biological_processGO:0050931 pigment cell differentiation IMP
 biological_processGO:0071600 otic vesicle morphogenesis IMP
 biological_processGO:1904888 cranial skeletal system development IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000030 macula utricle macula utricle physical object quality , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
otic vesicle shape , abnormal
otic vesicle epithelial cell apoptotic , abnormal
otic vesicle hair cell increased amount , abnormal
otic vesicle distended , abnormal
otic vesicle anterior region physical object quality , abnormal
Show

 ZFA:0000075 spinal cord spinal cord dorsal side apoptotic , abnormal
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 ZFA:0000166 lateral crista lateral crista physical object quality , abnormal
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 ZFA:0000168 anterior macula anterior macula mislocalised , abnormal
anterior macula fused with posterior macula , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve sodium channel complex asymmetrical , abnormal
posterior lateral line nerve sodium channel complex elongated , abnormal
posterior lateral line nerve sodium channel complex undistributed , abnormal
posterior lateral line nerve sodium channel complex decreased amount , abnormal
posterior lateral line nerve mislocalised , abnormal
posterior lateral line nerve defasciculated , abnormal
posterior lateral line nerve axon decreased amount , abnormal
posterior lateral line nerve myelin sheath absent , abnormal
posterior lateral line nerve myelinating Schwann cell absent , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion mislocalised , abnormal
dorsal root ganglion decreased amount , abnormal
dorsal root ganglion irregular spatial pattern , abnormal
dorsal root ganglion absent , abnormal
dorsal root ganglion increased amount , abnormal
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 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear malformed , abnormal
inner ear decreased size , abnormal
Show

 ZFA:0000225 lateral crista primordium lateral crista primordium physical object quality , abnormal
lateral crista primordium aplastic , abnormal
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 ZFA:0000243 neuromast neuromast quality , abnormal
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 ZFA:0000262 posterior semicircular canal posterior semicircular canal aplastic , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000314 anterior semicircular canal anterior semicircular canal aplastic , abnormal
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 ZFA:0000368 integument integument lacks all parts of type pigment cell , abnormal
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 ZFA:0000386 macula macula hair cell mislocalised , abnormal
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 ZFA:0000411 posterior crista primordium posterior crista primordium physical object quality , abnormal
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 ZFA:0000431 semicircular canal semicircular canal physical object quality , abnormal
semicircular canal decreased thickness , abnormal
semicircular canal morphology , abnormal
semicircular canal malformed , abnormal
semicircular canal disorganized , abnormal
Show

 ZFA:0000554 olfactory epithelium olfactory epithelium lacks parts or has fewer parts of type olfactory epithelium microvillous olfactory receptor neuron, abnormal
olfactory epithelium microvillous olfactory receptor neuron disorganized , abnormal
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 ZFA:0000558 posterior macula posterior macula mislocalised , abnormal
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 ZFA:0000559 otolith organ otolith organ decreased size , abnormal
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 ZFA:0000566 posterior crista posterior crista physical object quality , abnormal
posterior crista hair cell increased amount , abnormal
Show

 ZFA:0000588 statoacoustic (VIII) ganglion statoacoustic (VIII) ganglion neuron apoptotic , abnormal
Show

 ZFA:0000619 anterior crista anterior crista physical object quality , abnormal
anterior crista hair cell increased amount , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast quality , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line glial cell absent , abnormal
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 ZFA:0001078 thymus thymus decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type melanoblast , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism absent , abnormal
whole organism decreased pigmentation , abnormal
whole organism Melanin decreased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head pigment cell absent , abnormal
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 ZFA:0001115 trunk trunk pigment cell absent , abnormal
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 ZFA:0001117 post-vent region post-vent region melanoblast decreased amount , abnormal
post-vent region increased curvature , abnormal
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 ZFA:0001155 enteric nervous system enteric nervous system glial cell decreased amount , abnormal
enteric nervous system neuron decreased amount , abnormal
enteric nervous system neuron absent , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch morphology , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch chondrocyte decreased amount , abnormal
pharyngeal arch neural crest cell decreased amount , abnormal
Show

 ZFA:0001334 presumptive enteric nervous system presumptive enteric nervous system aplastic , abnormal
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 ZFA:0001338 intestine intestine peristalsis increased occurrence , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage morphology , abnormal
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 ZFA:0001469 lateral line lateral line quality , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
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 ZFA:0001617 otolith otolith quality , abnormal
otolith decreased size , abnormal
otolith decreased distance otolith , abnormal
Show

 ZFA:0001634 perichondrium perichondrium disorganized , abnormal
perichondrium decreased amount , abnormal
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 ZFA:0005850 nucleus of the caudal commissure nucleus of the caudal commissure decreased amount , abnormal
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 ZFA:0007067 vagal ganglion vagal ganglion malformed , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009046 T cell T cell decreased amount , abnormal
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 ZFA:0009052 motor neuron motor neuron axon structure , abnormal
motor neuron axon defasciculated , abnormal
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 ZFA:0009073 glial cell glial cell mislocalised , abnormal
glial cell filopodium increased speed , abnormal
glial cell filopodium increased length , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
pigment cell irregular spatial pattern , abnormal
pigment cell spatial pattern , abnormal
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 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte quality , abnormal
melanocyte absent , abnormal
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 ZFA:0009135 myelinating Schwann cell myelinating Schwann cell absent , abnormal
myelinating Schwann cell morphology , abnormal
myelinating Schwann cell decreased distribution , abnormal
myelinating Schwann cell decreased amount , abnormal
myelinating Schwann cell myelination disrupted , abnormal
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 ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
neural crest cell apoptotic , abnormal
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 ZFA:0009198 xanthophore xanthophore quality , abnormal
xanthophore dead , abnormal
xanthophore morphology , abnormal
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 ZFA:0009199 iridophore iridophore decreased amount , abnormal
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 ZFA:0009249 melanoblast melanoblast decreased amount , abnormal
melanoblast absent , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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