ENSDARG00000058598


Danio rerio

Features
Gene ID: ENSDARG00000058598
  
Biological name :sox18
  
Synonyms : sox18 / SRY (sex determining region Y)-box 18
  
Possible biological names infered from orthology : P35713 / P43680 / SRY-box 18 / Transcription factor SOX-18
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 8797143
Gene end: 8799880
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000113837
NCBI entrez gene - 797246     See in Manteia.
swissprot - E7F9I2
ZFIN ID - ZDB-GENE-080725-1
Ensembl - ENSDARG00000058598
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOX18ENSGALG00000034118Gallus gallus
 SOX18ENSG00000203883Homo sapiens
 Sox18ENSMUSG00000046470Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sox7 / SRY (sex determining region Y)-box 7 / Q9BT81* / P40646* / SRY-box 7* / AC105001.2*ENSDARG0000003012536
sox17 / SRY (sex determining region Y)-box 17 / Q9H6I2* / SRY-box 17*ENSDARG0000010171733
sox9a / SRY (sex determining region Y)-box 9a / SOX9* / Q04887* / P48436* / SRY-box 9* / Transcription factor SOX-9 *ENSDARG0000000329322
sox8a / SRY (sex determining region Y)-box 8a / SOX8* / P57073* / SRY-box 8*ENSDARG0000010530122
sox9b / SRY (sex determining region Y)-box 9b / SOX8* / P57073* / SRY-box 8*ENSDARG0000004392321
sox10 / SRY (sex determining region Y)-box 10 / Q04888* / P56693* / SRY-box 10* / Transcription factor SOX-10 *ENSDARG0000007746720
sox8b / SRY (sex determining region Y)-box 8b / SOX8* / P57073* / SRY-box 8*ENSDARG0000003778220
sox32 / SRY (sex determining region Y)-box 32 / SOX17* / Q9H6I2* / SRY-box 17*ENSDARG0000010059118
sox4b / SRY (sex determining region Y)-box 4b / SOX4* / Q06945* / SRY-box 4*ENSDARG0000009883418
sox4a / SRY (sex determining region Y)-box 4a / SOX4* / Q06945* / Q06831* / SRY-box 4* / Transcription factor SOX-4 *ENSDARG0000000458817
sox1a / Q6DGL6 / SRY (sex determining region Y)-box 1a / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *ENSDARG0000006986616
sox2 / Q6P0E1 / SRY (sex determining region Y)-box 2 / P48431* / SRY-box 2*ENSDARG0000007091316
sox1b / Q2Z1R2 / SRY (sex determining region Y)-box 1b / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *ENSDARG0000000813116
sox11a / SRY (sex determining region Y)-box 11a / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *ENSDARG0000007781115
sox11b / SRY (sex determining region Y)-box 11b / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *ENSDARG0000009574315
sox12 / SRY (sex determining region Y)-box 12 / Q04890* / O15370* / SRY-box 12* / Transcription factor SOX-12 *ENSDARG0000002584715
sox3 / Q6EJB7 / SRY (sex determining region Y)-box 3 / P41225* / SRY-box 3*ENSDARG0000005356915
P47792 / sox19a / SRY (sex determining region Y)-box 19aENSDARG0000001077014
sox21a / SRY (sex determining region Y)-box 21aENSDARG0000003166414
sox14 / Q32PP9 / SRY (sex determining region Y)-box 14 / Q04892* / O95416* / SRY-box 14* / Transcription factor SOX-14 *ENSDARG0000007092913


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR021934  Sox, C-terminal
 IPR033392  Sox 7/17/18, central domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001570 vasculogenesis IGI
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0060840 artery development IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta morphology , abnormal
dorsal aorta lateral region in contact with common cardinal vein , abnormal
dorsal aorta fused with posterior cardinal vein , abnormal
dorsal aorta blood vessel development process quality , abnormal
dorsal aorta blood vessel endothelium decreased amount , abnormal
dorsal aorta blood vessel endothelium absent , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein dilated , abnormal
posterior cardinal vein blood vessel endothelial cell mislocalised , abnormal
posterior cardinal vein morphology , abnormal
posterior cardinal vein regulation of transcription involved in venous endothelial cell fate commitment process quality , abnormal
posterior cardinal vein vascular sprouts decreased amount , abnormal
posterior cardinal vein vascular lymphangioblast absent , abnormal
posterior cardinal vein vascular lymphangioblast decreased amount , abnormal
posterior cardinal vein intersegmental vein decreased amount , abnormal
posterior cardinal vein endothelial cell increased amount , abnormal
posterior cardinal vein blood vessel development process quality , abnormal
posterior cardinal vein blood vessel endothelium decreased amount , abnormal
posterior cardinal vein blood vessel endothelium absent , abnormal
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 ZFA:0000671 horizontal myoseptum horizontal myoseptum vascular lymphangioblast decreased amount , abnormal
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 ZFA:0001054 lateral dorsal aorta lateral dorsal aorta morphology , abnormal
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 ZFA:0001073 axial vasculature axial vasculature physical object quality , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type dorsal aorta , abnormal
whole organism decreased amount , abnormal
whole organism increased amount , abnormal
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 ZFA:0001115 trunk trunk blood circulation decreased occurrence , abnormal
trunk intersegmental vein decreased amount , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel increased circumference , abnormal
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 ZFA:0001286 caudal vein plexus caudal vein plexus decreased size , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature disorganized , abnormal
trunk vasculature increased circumference , abnormal
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 ZFA:0005110 thoracic duct thoracic duct morphology , abnormal
thoracic duct aplastic/hypoplastic , abnormal
thoracic duct aplastic , abnormal
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 ZFA:0005257 blood vessel endothelium blood vessel endothelium decreased amount , abnormal
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 ZFA:0005295 axial blood vessel axial blood vessel decreased amount , abnormal
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 ZFA:0009265 monocyte monocyte decreased amount , abnormal
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 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
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 ZFA:0009395 vascular lymphangioblast vascular lymphangioblast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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