ENSDARG00000100591


Danio rerio

Features
Gene ID: ENSDARG00000100591
  
Biological name :sox32
  
Synonyms : sox32 / SRY (sex determining region Y)-box 32
  
Possible biological names infered from orthology : Q61473 / Q9H6I2 / SOX17 / SRY-box 17 / Transcription factor SOX-17
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 58823406
Gene end: 58826164
  
Corresponding Affymetrix probe sets: Dr.12573.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000138262
swissprot - A0A0R4IRI6
ZFIN ID - ZDB-GENE-011026-1
Ensembl - ENSDARG00000100591
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000032994Gallus gallus
 SOX17ENSGALG00000032851Gallus gallus
 SOX17ENSG00000164736Homo sapiens
 Sox17ENSMUSG00000025902Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sox7 / SRY (sex determining region Y)-box 7 / Q9BT81* / P40646* / SRY-box 7* / AC105001.2*ENSDARG0000003012527
sox18 / SRY (sex determining region Y)-box 18 / P43680* / P35713* / SRY-box 18* / Transcription factor SOX-18 *ENSDARG0000005859825
sox17 / SRY (sex determining region Y)-box 17 / Q9H6I2* / SRY-box 17*ENSDARG0000010171725
sox9a / SRY (sex determining region Y)-box 9a / SOX9* / Q04887* / P48436* / SRY-box 9* / Transcription factor SOX-9 *ENSDARG0000000329322
sox9b / SRY (sex determining region Y)-box 9b / SOX8* / P57073* / SRY-box 8*ENSDARG0000004392320
sox10 / SRY (sex determining region Y)-box 10 / Q04888* / P56693* / SRY-box 10* / Transcription factor SOX-10 *ENSDARG0000007746720
sox1a / Q6DGL6 / SRY (sex determining region Y)-box 1a / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *ENSDARG0000006986618
sox8a / SRY (sex determining region Y)-box 8a / SOX8* / P57073* / SRY-box 8*ENSDARG0000010530118
sox1b / Q2Z1R2 / SRY (sex determining region Y)-box 1b / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *ENSDARG0000000813118
sox8b / SRY (sex determining region Y)-box 8b / SOX8* / P57073* / SRY-box 8*ENSDARG0000003778217
sox14 / Q32PP9 / SRY (sex determining region Y)-box 14 / Q04892* / O95416* / SRY-box 14* / Transcription factor SOX-14 *ENSDARG0000007092917
FQ377628.2ENSDARG0000011196916
sox21a / SRY (sex determining region Y)-box 21aENSDARG0000003166416
sox11b / SRY (sex determining region Y)-box 11b / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *ENSDARG0000009574316
sox4b / SRY (sex determining region Y)-box 4b / SOX4* / Q06945* / SRY-box 4*ENSDARG0000009883416
sox4a / SRY (sex determining region Y)-box 4a / SOX4* / Q06945* / Q06831* / SRY-box 4* / Transcription factor SOX-4 *ENSDARG0000000458816
sox3 / Q6EJB7 / SRY (sex determining region Y)-box 3 / P41225* / SRY-box 3*ENSDARG0000005356916
Q6RVD7 / sox21b / SRY (sex determining region Y)-box 21b / SOX21* / Q9Y651* / Q811W0* / SRY-box 21* / Transcription factor SOX-21 *ENSDARG0000000854015
sox19b / SRY (sex determining region Y)-box 19bENSDARG0000004026615
sox2 / Q6P0E1 / SRY (sex determining region Y)-box 2 / P48431* / SRY-box 2*ENSDARG0000007091315


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001706 endoderm formation IMP
 biological_processGO:0001885 endothelial cell development IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003262 endocardial progenitor cell migration to the midline involved in heart field formation IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007493 endodermal cell fate determination IMP
 biological_processGO:0007498 mesoderm development IDA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035701 hematopoietic stem cell migration IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0042663 regulation of endodermal cell fate specification IGI
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0061035 regulation of cartilage development IMP
 cellular_componentGO:0005634 nucleus IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IGI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle absent , abnormal
Show

 ZFA:0000017 endoderm endoderm morphology , abnormal
endoderm aplastic , abnormal
endoderm absent , abnormal
endoderm mislocalised , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group absent , abnormal
Show

 ZFA:0000031 hypochord hypochord decreased length , abnormal
Show

 ZFA:0000041 mesoderm mesoderm apical junction complex mislocalised , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000066 proctodeum proctodeum absent , abnormal
Show

 ZFA:0000106 extension extension increased thickness , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle collapsed , abnormal
Show

 ZFA:0000114 heart heart cleft , abnormal
heart quality , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment split , abnormal
Show

 ZFA:0000117 hypoblast hypoblast lacks all parts of type endodermal cell , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm establishment of epithelial cell apical/basal polarity decreased process quality , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct absent , abnormal
pronephric duct mislocalised laterally , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle collapsed , abnormal
Show

 ZFA:0000270 maxilla maxilla decreased size , abnormal
Show

 ZFA:0000360 heart tube heart tube duplicated , abnormal
Show

 ZFA:0000823 rhombomere 5 rhombomere 5 branchiomotor neuron mislocalised anteriorly , abnormal
Show

 ZFA:0001054 lateral dorsal aorta lateral dorsal aorta malformed , abnormal
Show

 ZFA:0001073 axial vasculature axial vasculature morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism decreased behavioural activity , abnormal
whole organism lacks all parts of type endoderm , abnormal
whole organism increased amount , abnormal
Show

 ZFA:0001104 pharyngeal endoderm pharyngeal endoderm morphology , abnormal
pharyngeal endoderm aplastic , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage shape , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton apoptotic , abnormal
mandibular arch skeleton shape , abnormal
mandibular arch skeleton size , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased size , abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton apoptotic , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
Show

 ZFA:0001296 glossopharyngeal placode glossopharyngeal placode poorly differentiated , abnormal
Show

 ZFA:0001301 glossopharyngeal ganglion glossopharyngeal ganglion poorly differentiated , abnormal
Show

 ZFA:0001302 vagal ganglion 1 vagal ganglion 1 poorly differentiated , abnormal
Show

 ZFA:0001303 vagal ganglion 2 vagal ganglion 2 poorly differentiated , abnormal
Show

 ZFA:0001304 vagal ganglion 3 vagal ganglion 3 poorly differentiated , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch aplastic , abnormal
Show

 ZFA:0001338 intestine intestine absent , abnormal
Show

 ZFA:0001379 pharyngeal ectoderm pharyngeal ectoderm disorganized , abnormal
pharyngeal ectoderm increased area , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
palatoquadrate cartilage shape , abnormal
Show

 ZFA:0001401 dorsal hyoid arch dorsal hyoid arch decreased size , abnormal
dorsal hyoid arch shape , abnormal
Show

 ZFA:0001402 ventral hyoid arch ventral hyoid arch decreased size , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage decreased size , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage aplastic , abnormal
pharyngeal arch cartilage associated with pharyngeal arch cartilage , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule morphology , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 decreased size , abnormal
pharyngeal arch 3-7 fused with pharyngeal arch 3-7 , abnormal
Show

 ZFA:0005237 erythroblast erythroblast mislocalised laterally , abnormal
Show

 ZFA:0005463 oral ectoderm oral ectoderm mislocalised dorsally , abnormal
oral ectoderm mislocalised laterally , abnormal
oral ectoderm hypoplastic , abnormal
oral ectoderm disorganized , abnormal
oral ectoderm mislocalised anteriorly , abnormal
Show

 ZFA:0005605 lymphangioblast cord lymphangioblast cord decreased length , abnormal
Show

 ZFA:0009165 neural crest cell neural crest cell mislocalised , abnormal
Show

 ZFA:0009288 primordial germ cell primordial germ cell aggregated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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