ENSDARG00000053569


Danio rerio

Features
Gene ID: ENSDARG00000053569
  
Biological name :sox3
  
Synonyms : Q6EJB7 / sox3 / SRY (sex determining region Y)-box 3
  
Possible biological names infered from orthology : P41225 / SRY-box 3
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 32742701
Gene end: 32744464
  
Corresponding Affymetrix probe sets: Dr.1691.12.S1_at (Zebrafish Array)   Dr.18836.3.S1_at (Zebrafish Array)   Dr.20010.8.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000070099
NCBI entrez gene - 30529     See in Manteia.
RefSeq - NM_001001811
RefSeq Peptide - NP_001001811
swissprot - A9JSZ3
swissprot - Q6EJB7
ZFIN ID - ZDB-GENE-980526-333
Ensembl - ENSDARG00000053569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOX3ENSG00000134595Homo sapiens
 Sox3ENSMUSG00000045179Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sox2 / Q6P0E1 / SRY (sex determining region Y)-box 2 / P48431* / SRY-box 2*ENSDARG0000007091367
sox1b / Q2Z1R2 / SRY (sex determining region Y)-box 1b / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *ENSDARG0000000813163
sox1a / Q6DGL6 / SRY (sex determining region Y)-box 1a / SOX1* / P53783* / O00570* / SRY-box 1* / Transcription factor SOX-1 *ENSDARG0000006986662
P47792 / sox19a / SRY (sex determining region Y)-box 19aENSDARG0000001077053
sox19b / SRY (sex determining region Y)-box 19bENSDARG0000004026653
sox14 / Q32PP9 / SRY (sex determining region Y)-box 14 / Q04892* / O95416* / SRY-box 14* / Transcription factor SOX-14 *ENSDARG0000007092935
FQ377628.2ENSDARG0000011196934
Q6RVD7 / sox21b / SRY (sex determining region Y)-box 21b / SOX21* / Q9Y651* / Q811W0* / SRY-box 21* / Transcription factor SOX-21 *ENSDARG0000000854034
sox21a / SRY (sex determining region Y)-box 21aENSDARG0000003166434
sox12 / SRY (sex determining region Y)-box 12 / Q04890* / O15370* / SRY-box 12* / Transcription factor SOX-12 *ENSDARG0000002584726
sox9a / SRY (sex determining region Y)-box 9a / SOX9* / Q04887* / P48436* / SRY-box 9* / Transcription factor SOX-9 *ENSDARG0000000329324
sox7 / SRY (sex determining region Y)-box 7 / Q9BT81* / P40646* / SRY-box 7* / AC105001.2*ENSDARG0000003012524
sox11b / SRY (sex determining region Y)-box 11b / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *ENSDARG0000009574324
sox9b / SRY (sex determining region Y)-box 9b / SOX8* / P57073* / SRY-box 8*ENSDARG0000004392324
sox11a / SRY (sex determining region Y)-box 11a / SOX11* / Q7M6Y2* / P35716* / SRY-box 11* / Transcription factor SOX-11 *ENSDARG0000007781123
sox17 / SRY (sex determining region Y)-box 17 / Q9H6I2* / SRY-box 17*ENSDARG0000010171723
sox4a / SRY (sex determining region Y)-box 4a / SOX4* / Q06945* / Q06831* / SRY-box 4* / Transcription factor SOX-4 *ENSDARG0000000458823
sox4b / SRY (sex determining region Y)-box 4b / SOX4* / Q06945* / SRY-box 4*ENSDARG0000009883423
sox10 / SRY (sex determining region Y)-box 10 / Q04888* / P56693* / SRY-box 10* / Transcription factor SOX-10 *ENSDARG0000007746723
sox8a / SRY (sex determining region Y)-box 8a / SOX8* / P57073* / SRY-box 8*ENSDARG0000010530123


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022097  Transcription factor SOX


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0043049 otic placode formation IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain decreased size , abnormal
brain apoptotic , abnormal
brain nucleus decreased amount , abnormal
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 ZFA:0000012 central nervous system central nervous system abnormal , abnormal
central nervous system apoptotic , abnormal
Show

 ZFA:0000041 mesoderm mesoderm increased width , abnormal
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 ZFA:0000051 otic vesicle otic vesicle morphology , abnormal
otic vesicle decreased size , abnormal
otic vesicle aplastic , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate increased distance notochord , abnormal
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 ZFA:0000075 spinal cord spinal cord nucleus decreased amount , abnormal
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 ZFA:0000077 tail bud tail bud aplastic , abnormal
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 ZFA:0000092 axis axis shortened , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000132 neural plate neural plate increased width , abnormal
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 ZFA:0000135 notochord notochord broad , abnormal
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 ZFA:0000155 somite somite malformed , abnormal
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 ZFA:0000938 central canal central canal unlumenized , abnormal
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 ZFA:0001058 caudal fin caudal fin deformed , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism truncated , abnormal
whole organism decreased length , abnormal
whole organism lacks all parts of type facial ganglion , abnormal
whole organism lacks all parts of type glossopharyngeal ganglion , abnormal
whole organism lacks all parts of type vagal ganglion 1 , abnormal
whole organism lacks all parts of type vagal ganglion 2 , abnormal
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 ZFA:0001114 head head aplastic , abnormal
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 ZFA:0001309 neurogenic placode neurogenic placode morphology , abnormal
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 ZFA:0001311 roof plate rhombomere region roof plate rhombomere region left-right axis decreased width , abnormal
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 ZFA:0001555 epibranchial ganglion epibranchial ganglion decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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