ENSMUSG00000032368


Mus musculus

Features
Gene ID: ENSMUSG00000032368
  
Biological name :Zic1
  
Synonyms : P46684 / Zic1 / zinc finger protein of the cerebellum 1
  
Possible biological names infered from orthology : Q15915 / Zic family member 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.2
Gene start: 91358058
Gene end: 91365810
  
Corresponding Affymetrix probe sets: 10595695 (MoGene1.0st)   1423477_at (Mouse Genome 430 2.0 Array)   1439627_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034927
Ensembl peptide - ENSMUSP00000068858
NCBI entrez gene - 22771     See in Manteia.
MGI - MGI:106683
RefSeq - XM_006511061
RefSeq - NM_009573
RefSeq Peptide - NP_033599
swissprot - P46684
Ensembl - ENSMUSG00000032368
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZIC1ENSG00000152977Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zic2 / zinc finger protein of the cerebellum 2 / O95409* / Zic family member 2*ENSMUSG0000006152476
Zic3 / Q62521 / zinc finger protein of the cerebellum 3 / O60481* / Zic family member 3*ENSMUSG0000006786068
Zic5 / zinc finger protein of the cerebellum 5 / Q96T25* / Zic family member 5*ENSMUSG0000004170350
Zic4 / Q61467 / zinc finger protein of the cerebellum 4 / Q8N9L1* / Zic family member 4*ENSMUSG0000003697244
Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*ENSMUSG0000002131831
Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*ENSMUSG0000004840230
Gli1 / P47806 / Zinc finger protein GLI1 / P08151* / GLI family zinc finger 1*ENSMUSG0000002540726
Glis3 / Q6XP49 / Zinc finger protein GLIS3 / Q8NEA6* / GLIS family zinc finger 3*ENSMUSG0000005294226
Glis1 / Q8K1M4 / Zinc finger protein GLIS1 / Q8NBF1* / GLIS family zinc finger 1*ENSMUSG0000003476224
Glis2 / Q8VDL9 / Zinc finger protein GLIS2 / Q9BZE0* / GLIS family zinc finger 2*ENSMUSG0000001430321


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IDA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007420 brain development IDA
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0008589 regulation of smoothened signaling pathway IPI
 biological_processGO:0021510 spinal cord development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IDA
 biological_processGO:0042472 inner ear morphogenesis ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Zic1tm1Jaru/Zic1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C3H/HeN

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Zic1tm1Jaru/Zic1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C3H/HeN

 MP:0000866 vermis hypoplasia "reduced cell number in the vermis" [J:61509]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Raf1tm2Bacc/Raf1tm2Bacc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Myo5ad+Ha/Myo5ad+Ha
Genetic Background: DBA/2Ha-Myo5ad+Ha

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad+Ha/Myo5ad+Ha
Genetic Background: DBA/2Ha-Myo5ad+Ha

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zic1/Zic4tm1Kjmi/Zic1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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