| MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: Sptbn4qv-lnd/Sptbn4qv-lnd
Genetic Background: B6.B10-Sptbn4qv-lnd
Allelic Composition: Aqp2tm1Nlsn/Aqp2tm1Nlsn,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Aqp2tm1.1Nlsn/Aqp2tm1.1Nlsn
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000536 | hydroureter | "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000538 | abnormal urinary bladder morphology | "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hprttm1Dhm/Y,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Mc4rY302C/Mc4rY302C
Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0001270 | distended abdomen | "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0001426 | polydipsia | "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Sptbn4qv-lnd/Sptbn4qv-lnd
Genetic Background: B6.B10-Sptbn4qv-lnd
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001429 | dehydration | "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001510 | abnormal coat appearance | "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Aqp2tm1Nlsn/Aqp2tm1Nlsn,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0001762 | polyuria | "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2F204V/Aqp2F204V
Genetic Background: C57BL/6-Aqp2F204V
Allelic Composition: Aqp2tm1Nlsn/Aqp2tm1Nlsn,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0001924 | infertility | "inability to produce live offspring" [J:47225] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0002136 | abnormal kidney physiology | "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Sptbn4qv-lnd/Sptbn4qv-lnd
Genetic Background: B6.B10-Sptbn4qv-lnd
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| MP:0002608 | increased hematocrit | "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N
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| MP:0002987 | abnormal urine osmolarity | "changes in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000] |
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Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002988 | decreased urine osmolarity | "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: Aqp2F204V/Aqp2F204V
Genetic Background: C57BL/6-Aqp2F204V
Allelic Composition: Aqp2tm1Nlsn/Aqp2tm1Nlsn,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003014 | abnormal kidney medulla morphology | "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N
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| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003853 | dry skin | "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004192 | abnormal kidney pyramid morphology | "any structural anomaly of the conical mass of tissue, containing part of the secreting and collecting tubules, whose base faces the renal cortex" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0004194 | abnormal kidney pelvis morphology | "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0004860 | dilated kidney collecting duct | "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0008997 | increased blood osmolality | "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0009643 | abnormal urine homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: Aqp2tm1.1Nlsn/Aqp2tm1.1Nlsn
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Aqp2tm1Nlsn/Aqp2tm1Nlsn,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0011304 | kidney papillary atrophy | "acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: Aqp2tm1Nlsn/Aqp2tm1Nlsn,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Aqp2tm1.1Nlsn/Aqp2tm1.1Nlsn
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011305 | dilated kidney calyx | "an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:anna] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0011307 | kidney medulla cysts | "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
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| MP:0011413 | colorless urine | "absence of the usual straw-coloration of the urine" [MGI:anna] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0011422 | kidney medulla atrophy | "acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J
Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
Allelic Composition: Aqp2tm1Bxy/Aqp2tm1Bxy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0011492 | ureterovesical junction obstruction | "a partial or total blockage of the valve-like structure found at the site of entry of the ureter into the urinary bladder" [MGI:anna] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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| MP:0011844 | kidney collecting duct atrophy | "acquired diminution of the size of the kidney collecting ducts associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Aqp2cph/Aqp2cph
Genetic Background: C57BL/6J-Aqp2cph
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